方便合成二氢苯并呋喃融合螺环戊烷-1,2-二吲哚啉酮支架

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC European Journal of Organic Chemistry Pub Date : 2024-10-17 DOI:10.1002/ejoc.202400777

Ting Tang, Ying Han, Chao-Guo Yan, Kun Huang, Jing Sun

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引用次数: 0

摘要

通过异汀和 3-(邻羟基亚苄基)吲哚啉-2-酮的 MBH 碳酸酯的碱促进多米诺环化反应，开发出一种具有高非对映选择性的多种功能化二氢苯并呋喃融合螺环戊烷-1,2-二吲哚啉-酮的简便合成方案。通过测定八种单晶结构，清楚地阐明了各种多环化合物的相对构型。

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Convenient Synthesis of Dihydrobenzofuran-Fused Spirocyclopentane-1,2-Diindolinone Scaffolds

A convenient synthetic protocol for diverse functionalized dihydrobenzofuran-fused spirocyclopentane-1,2-diindolin-ones with high diastereoselectivity is developed by base promoted domino annulation reaction of MBH carbonates of isatins and 3-(o-hydroxybenzylidene)indolin-2-ones. The relative configurations of the various polycyclic compounds are clearly elucidated by determination eight single crystal structures.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.