{"title":"Sahacharadi Kwatha 的质量参数和防腐剂浓度分析：三种商业品牌的比较研究","authors":"Sangeetha Gopal, Leon Ittiachen","doi":"10.1016/j.jaim.2024.101029","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div><em>Sahacharadi Kwatha</em> is traditionally employed in Ayurvedic therapy for \"vata\" related conditions such as back pain, herniated disc, palsy, sciatica, and paralysis. Classical Ayurvedic texts recommend the use of freshly prepared Kwatha for optimal patient benefits. However, in response to the commercialization of Ayurveda and the demand for convenient over-the-counter (OTC) formulations, various commercial preservatives have been incorporated by Ayurvedic manufacturers to facilitate OTC preparation and prolong shelf life.</div></div><div><h3>Objectives</h3><div>This study aims to comprehensively analyse and compare the quality parameters and preservative content in three prominent brands of <em>Sahacharadi Kwatha</em> available in the Indian market.</div></div><div><h3>Materials and methods</h3><div>Organoleptic and physicochemical properties, phytochemical content, and microbial load of the samples were analyzed following standardized procedures. Sodium benzoate levels in the samples were determined using both titrimetric and High-Performance Liquid Chromatography (HPLC) methods. High-Performance Thin-Layer Chromatography (HPTLC) profiles were compared to discern differences among the samples.</div></div><div><h3>Results</h3><div>The study revealed significant variations in organoleptic and physicochemical properties, HPTLC profiles, and microbial load among the tested samples. Sodium benzoate levels in all samples exceeded the FDA and API-approved limit. Additionally, substantial variations were noted in the phytochemical content of the samples.</div></div><div><h3>Conclusion</h3><div>This investigation underscores noteworthy disparities in quality parameters and preservative content within the tested market variants of <em>Sahacharadi Kwatha</em>. The findings emphasize the existence of unregulated standards in the preparation of Ayurvedic medicines available in the market, highlighting the imperative for standardization and validation of Ayurvedic formulations. Such measures are essential for enhancing consumer acceptability and fostering the overall development and growth of the Ayurveda industry.</div></div>","PeriodicalId":15150,"journal":{"name":"Journal of Ayurveda and Integrative Medicine","volume":"15 5","pages":"Article 101029"},"PeriodicalIF":1.7000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of quality parameters and preservative concentrations in Sahacharadi Kwatha: A comparative study of three commercial brands\",\"authors\":\"Sangeetha Gopal, Leon Ittiachen\",\"doi\":\"10.1016/j.jaim.2024.101029\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div><em>Sahacharadi Kwatha</em> is traditionally employed in Ayurvedic therapy for \\\"vata\\\" related conditions such as back pain, herniated disc, palsy, sciatica, and paralysis. Classical Ayurvedic texts recommend the use of freshly prepared Kwatha for optimal patient benefits. However, in response to the commercialization of Ayurveda and the demand for convenient over-the-counter (OTC) formulations, various commercial preservatives have been incorporated by Ayurvedic manufacturers to facilitate OTC preparation and prolong shelf life.</div></div><div><h3>Objectives</h3><div>This study aims to comprehensively analyse and compare the quality parameters and preservative content in three prominent brands of <em>Sahacharadi Kwatha</em> available in the Indian market.</div></div><div><h3>Materials and methods</h3><div>Organoleptic and physicochemical properties, phytochemical content, and microbial load of the samples were analyzed following standardized procedures. Sodium benzoate levels in the samples were determined using both titrimetric and High-Performance Liquid Chromatography (HPLC) methods. High-Performance Thin-Layer Chromatography (HPTLC) profiles were compared to discern differences among the samples.</div></div><div><h3>Results</h3><div>The study revealed significant variations in organoleptic and physicochemical properties, HPTLC profiles, and microbial load among the tested samples. Sodium benzoate levels in all samples exceeded the FDA and API-approved limit. Additionally, substantial variations were noted in the phytochemical content of the samples.</div></div><div><h3>Conclusion</h3><div>This investigation underscores noteworthy disparities in quality parameters and preservative content within the tested market variants of <em>Sahacharadi Kwatha</em>. The findings emphasize the existence of unregulated standards in the preparation of Ayurvedic medicines available in the market, highlighting the imperative for standardization and validation of Ayurvedic formulations. Such measures are essential for enhancing consumer acceptability and fostering the overall development and growth of the Ayurveda industry.</div></div>\",\"PeriodicalId\":15150,\"journal\":{\"name\":\"Journal of Ayurveda and Integrative Medicine\",\"volume\":\"15 5\",\"pages\":\"Article 101029\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Ayurveda and Integrative Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S097594762400144X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Ayurveda and Integrative Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S097594762400144X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
背景Sahacharadi Kwatha 传统上用于阿育吠陀疗法，治疗与 "瓦塔 "有关的疾病，如背痛、椎间盘突出、麻痹、坐骨神经痛和瘫痪。经典的阿育吠陀经文建议使用新鲜制备的 Kwatha，以使患者获得最佳疗效。然而，随着阿育吠陀的商业化和对方便的非处方药（OTC）配方的需求，阿育吠陀制造商加入了各种商业防腐剂，以方便非处方药的制备并延长保质期。本研究旨在全面分析和比较印度市场上三种著名品牌的 Sahacharadi Kwatha 的质量参数和防腐剂含量。使用滴定法和高效液相色谱法测定了样品中的苯甲酸钠含量。研究结果表明，被测样品在感官和理化特性、HPTLC 图谱以及微生物量方面存在显著差异。所有样品中的苯甲酸钠含量都超过了 FDA 和 API 批准的限值。此外，样品中的植物化学成分含量也存在很大差异。调查结果表明，市场上阿育吠陀药物的制备标准不规范，因此必须对阿育吠陀配方进行标准化和验证。这些措施对于提高消费者的接受度、促进阿育吠陀产业的整体发展和增长至关重要。
Analysis of quality parameters and preservative concentrations in Sahacharadi Kwatha: A comparative study of three commercial brands
Background
Sahacharadi Kwatha is traditionally employed in Ayurvedic therapy for "vata" related conditions such as back pain, herniated disc, palsy, sciatica, and paralysis. Classical Ayurvedic texts recommend the use of freshly prepared Kwatha for optimal patient benefits. However, in response to the commercialization of Ayurveda and the demand for convenient over-the-counter (OTC) formulations, various commercial preservatives have been incorporated by Ayurvedic manufacturers to facilitate OTC preparation and prolong shelf life.
Objectives
This study aims to comprehensively analyse and compare the quality parameters and preservative content in three prominent brands of Sahacharadi Kwatha available in the Indian market.
Materials and methods
Organoleptic and physicochemical properties, phytochemical content, and microbial load of the samples were analyzed following standardized procedures. Sodium benzoate levels in the samples were determined using both titrimetric and High-Performance Liquid Chromatography (HPLC) methods. High-Performance Thin-Layer Chromatography (HPTLC) profiles were compared to discern differences among the samples.
Results
The study revealed significant variations in organoleptic and physicochemical properties, HPTLC profiles, and microbial load among the tested samples. Sodium benzoate levels in all samples exceeded the FDA and API-approved limit. Additionally, substantial variations were noted in the phytochemical content of the samples.
Conclusion
This investigation underscores noteworthy disparities in quality parameters and preservative content within the tested market variants of Sahacharadi Kwatha. The findings emphasize the existence of unregulated standards in the preparation of Ayurvedic medicines available in the market, highlighting the imperative for standardization and validation of Ayurvedic formulations. Such measures are essential for enhancing consumer acceptability and fostering the overall development and growth of the Ayurveda industry.
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