Shuaixing Liu , Jiaqi Liu , Liangrui Yang , Shengqi Zhang , Fengmei Zhang , Le Cai
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A new 2-pyrrolidinone from Cladosporium sp. associated with Rubus tephrodes
The cultivation of Cladosporium sp., a fungus found in association with Rubus tephrodes Hance, resulted in the identification of sixteen compounds. New compound cladosporlactam (1) was distinguished by featuring a skeleton linked to a furan unit, with 3,4-dihydroxypyrrolidine-2-ketone as its characteristic structure. The structure of cladosporlactam was elucidated through meticulous analyses using NMR, electronic circular dichroism (ECD) calculations. Compound 1 could cause a gradual reduction in lipid droplets in a dose-dependent manner without inducing cytotoxicity and demonstrated intermediate antimicrobial activity against Staphylococcus aureus with MIC values of 8 μg/mL.
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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