以淀粉样蛋白-β为主的阿尔茨海默病神经病理变化。

IF 10.6 1区医学 Q1 CLINICAL NEUROLOGY Brain Pub Date : 2024-10-17 DOI:10.1093/brain/awae325

Gabor G Kovacs,Yuriko Katsumata,Xian Wu,Khine Zin Aung,David W Fardo,Shelley L Forrest,,Peter T Nelson

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引用次数: 0

摘要

阿尔茨海默病神经病理学变化（ADNC）的不同亚群，包括具有严重/广泛 Aβ 斑块但无/轻度 tau 结（Aβ-predominant ADNC，或 AP-ADNC）的令人感兴趣的个体，可能具有不同的遗传和临床特征。通过分析国家阿尔茨海默氏症协调中心的数据，我们将 1,187 名参与者分为 AP-ADNC （n = 95）、低布拉克原发性年龄相关牛头蛋白病（PART；n = 185）、典型-ADNC（n = 832）和高布拉克 PART（n = 75）。AP-ADNC 在某些临床特征和 APOE、SNX1、WNT3/MAPT 和 IGH 基因的遗传多态性方面存在差异。我们的结论是，AP-ADNC 不同于传统的 ADNC，对体内研究具有重要意义。

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Amyloid-β predominant Alzheimer's disease neuropathologic change.

Different subsets of Alzheimer's disease neuropathologic change (ADNC), including the intriguing set of individuals with severe/widespread Aβ plaques but no/mild tau tangles (Aβ-predominant ADNC, or AP-ADNC), may have distinct genetic and clinical features. Analyzing National Alzheimer's Coordinating Center data, we stratified 1,187 participants into AP-ADNC (n = 95), low Braak primary age related tauopathy (PART; n = 185), typical-ADNC (n = 832), and high-Braak PART (n = 75). AP-ADNC differed in some clinical features and genetic polymorphisms in the APOE, SNX1, WNT3/MAPT, and IGH genes. We conclude that AP-ADNC differs from classical ADNC with implications for in vivo studies.

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来源期刊

Brain 医学-临床神经学

CiteScore

20.30

自引率

4.10%

发文量

458

审稿时长

3-6 weeks

期刊介绍： Brain, a journal focused on clinical neurology and translational neuroscience, has been publishing landmark papers since 1878. The journal aims to expand its scope by including studies that shed light on disease mechanisms and conducting innovative clinical trials for brain disorders. With a wide range of topics covered, the Editorial Board represents the international readership and diverse coverage of the journal. Accepted articles are promptly posted online, typically within a few weeks of acceptance. As of 2022, Brain holds an impressive impact factor of 14.5, according to the Journal Citation Reports.