咪唑杂环电化学功能化的最新进展

IF 4.4 2区 化学 Q2 CHEMISTRY, APPLIED Advanced Synthesis & Catalysis Pub Date : 2024-10-17 DOI:10.1002/adsc.202401064
Sifeng Li
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引用次数: 0

摘要

咪唑杂环在制药业和农用化学品中有着广泛的应用。本文全面概述了电化学功能化的最新进展,并将其分为十种不同类型的反应。电化学合成已成为生产有机分子的一种高效方法,尤其是在可持续发展的背景下。利用电子作为无迹氧化剂,在 C3 或 C5 位实现了咪唑并杂环的多种 C-H 功能化反应。电子可以作为还原剂,合成部分或完全饱和的吡啶环咪唑并[1,2-a]吡啶。本综述旨在吸引科学界的兴趣,并促进利用电化学方法对咪唑三环进行功能化的更多研究。
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Recent Advances in the Electrochemical Functionalization of Imidazoheterocycles
Imidazoheterocycles have extensive applications in the pharmaceutical industry and agrochemicals. A comprehensive overview has been provided on the current advancements in electrochemical functionalization, which has been classified ten different types of reactions. Electrochemical synthesis has emerged as a highly effective method for producing organic molecules, especially in the context of sustainable development. Employing electrons as the traceless oxidant, several C–H functionalization reactions of imidazo-fused heterocycles have been achieved at either the C3 or C5 positions. Electrons may serve as the reducing agent to synthesize pyridine rings that are either partially or fully saturated in imidazo[1,2-a]pyridines. The purpose of the review is to attract the interest of the scientific community and promote additional research on the functionalization of imidazoheterocycles using electrochemical methods.
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来源期刊
Advanced Synthesis & Catalysis
Advanced Synthesis & Catalysis 化学-应用化学
CiteScore
9.40
自引率
7.40%
发文量
447
审稿时长
1.8 months
期刊介绍: Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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