通过个性化包裹引导经颅磁刺激治疗重度抑郁症和广泛性焦虑症患者的睡眠质量改善情况

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES Brain and Behavior Pub Date : 2024-10-17 DOI:10.1002/brb3.70088
Si Jie Tang, Jonas Holle, Sirjan Mor, Nicholas B. Dadario, Mark Ryan, Charles Teo, Michael Sughrue, Jacky Yeung
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引用次数: 0

摘要

导言:睡眠质量差经常被认为是导致重度抑郁症(MDD)和广泛性焦虑症(GAD)等情感障碍患者生活质量下降的一个原因。由于睡眠和情感障碍受多网络相互作用的影响,我们假设通过个性化重复经颅磁刺激(rTMS)调节中央执行网络(CEN)、显著性和默认模式网络(DMNs)可能会改善睡眠和生活质量。 方法 从 2020 年到 2023 年,在 Cingulum Health 对情感障碍患者进行了回顾性分析。根据机器学习连通性软件从个体功能连通性网络中检测到的异常情况,选择了多个目标进行经颅磁刺激。在经颅磁刺激之前、之后和随访期间,对患者进行了匹兹堡睡眠质量指数(PSQI)、欧洲睡眠质量指数(EQ5D)、贝克抑郁量表(BDI)和一般焦虑症-7(GAD-7)问卷调查。 结果 确定了 27 名患者,最常见的诊断为 MDD(41%)或 MDD 伴 GAD(41%)。所有患者的 CEN 中至少有一个经颅磁刺激靶点。最常见的靶点(19 名患者)是背外侧前额叶皮层(dlPFC)的 L8Av。经颅磁刺激后和随访期间,患者的睡眠、生活质量、抑郁和焦虑症状均有明显改善。睡眠改善与随访期间的生活质量相关。 结论 本研究表明,个性化、包裹引导的经颅磁刺激是安全的,可持续改善情感障碍患者的睡眠、生活质量和情感症状。
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Improvements in Sleep Quality in Patients With Major Depressive and Generalized Anxiety Disorders Treated With Individualized, Parcel-Guided Transcranial Magnetic Stimulation

Introduction

Poor quality sleep has often been cited as a cause of lowered quality of life in patients with affective disorders such as major depressive disorder (MDD) and generalized anxiety disorder (GAD). As sleep and affective disorders are affected by multi-network interactions, we hypothesize that the modulation of the central executive network (CEN), salience, and default mode networks (DMNs) through individualized repetitive transcranial magnetic stimulation (rTMS) may improve sleep and quality of life.

Methods

A retrospective analysis from 2020 to 2023 was conducted in patients with affective disorders at Cingulum Health. Multiple targets were selected based on anomalies detected from individual, functional connectivity networks from a machine-learning connectivity software. rTMS was conducted with accelerated continuous or intermittent theta burst stimulation (TBS) based on the anomaly detected. Pittsburgh Sleep Quality Index (PSQI), EuroQol (EQ5D), Beck's Depression Inventory (BDI), and the General Anxiety Disorder-7 (GAD-7) questionnaires were administered prior to, after, and at follow-up of rTMS.

Results

Twenty-seven patients were identified, and the most common diagnoses were MDD (41%) or MDD with GAD (41%). All patients had at least one rTMS target in the CEN. The most common target (19 patients) was L8Av in the dorsolateral prefrontal cortex (dlPFC). Patients experienced significant improvements in sleep, quality of life, depressive, and anxiety symptoms after rTMS and during follow-up. Improvements in sleep correlated with quality of life at follow-up.

Conclusion

This study suggests that personalized, parcel-guided rTMS is safe and may provide sustained improvements in sleep, quality of life, and affective symptoms for patients with affective disorders.

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来源期刊
Brain and Behavior
Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES
CiteScore
5.30
自引率
0.00%
发文量
352
审稿时长
14 weeks
期刊介绍: Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)
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