A Chromium Catalytic System for the Synthesis of Aryl-Substituted 1,3,5-Triazines and Pyrimidines by Acceptorless Dehydrogenative Coupling

A novel and highly efficient methodology for the synthesis of 2,4,6-triaryl-1,3,5-triazines and 2,4,6-trisubstituted pyrimidines from amidines and alcohols has been established. Using the Earth-abundant and air-stable chromium salt catalyst and the phosphine-free ligand, the developed Cr-catalyzed acceptorless dehydrogenative coupling provides 1,3,5-triazines and pyrimidines with high yields and good functional group tolerance. Moreover, the synthetic value of this operationally simple protocol was demonstrated by gram-scale experiment and the synthesis of the linker to construct various supramolecular complexes.