三氟甲基化吡咯烷酮的光催化区域选择性串联环化协议

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC European Journal of Organic Chemistry Pub Date : 2024-10-21 DOI:10.1002/ejoc.202401023

Panpan Wang, Yuting Leng, Kaixia Sui, Shiliang Jiang, Ning Ma, Yangjie Wu

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引用次数: 0

摘要

我们开发出了一种制备三氟甲基化吡咯烷酮的新型环境友好型高效策略。该方法是利用可见光诱导 1,5 二烯与 CF3SO2Na 发生自由基环化反应，从而获得极佳的区域选择性。这种方法使用的三氟甲基化试剂成本较低且易于储存，因此是一种极具吸引力的选择。此外，所得到的三氟甲基化吡咯烷酮可以很容易地进行改性，初步的机理研究已经完成。

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Photocatalytic Regioselective Tandem Cyclization Protocol to Trifluoromethylated Pyrrolidones

A new environmentally friendly and efficient strategy for preparing trifluoromethylated pyrrolidones has been developed. The process involves using visible light to induce radical cyclization of 1,5-dienes with CF3SO2Na, resulting in excellent regioselectivity. This method uses less expensive and easy-to-store trifluoromethylation reagents, making it an attractive option. Additionally, the resulting trifluoromethylated pyrrolidones can be easily modified and preliminary mechanistic studies have been presented.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.