Hirotaka Murase , Mio Eto , Jeongsu Lee , Yosuke Taniguchi , Shuhei Imoto , Shigeki Sasaki
{"title":"寡核苷酸乙酰化试剂对 RNA 的 2'-OH 进行位点特异性乙酰化修饰","authors":"Hirotaka Murase , Mio Eto , Jeongsu Lee , Yosuke Taniguchi , Shuhei Imoto , Shigeki Sasaki","doi":"10.1039/d4cc04672b","DOIUrl":null,"url":null,"abstract":"<div><div>The method for a site-specific RNA acetylation using a novel oligonucleotide acetylating probe (Ac-probe) has been developed. It was confirmed that the acetyl group was site-specifically introduced to a 2′-OH of the sugar part of the target RNA <em>via</em> the formation of the RNA-probe duplex.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"60 91","pages":"Pages 13440-13442"},"PeriodicalIF":4.3000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Site-specific acetyl modification of 2′-OH of RNA by an oligonucleotide acetylating reagent†\",\"authors\":\"Hirotaka Murase , Mio Eto , Jeongsu Lee , Yosuke Taniguchi , Shuhei Imoto , Shigeki Sasaki\",\"doi\":\"10.1039/d4cc04672b\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The method for a site-specific RNA acetylation using a novel oligonucleotide acetylating probe (Ac-probe) has been developed. It was confirmed that the acetyl group was site-specifically introduced to a 2′-OH of the sugar part of the target RNA <em>via</em> the formation of the RNA-probe duplex.</div></div>\",\"PeriodicalId\":67,\"journal\":{\"name\":\"Chemical Communications\",\"volume\":\"60 91\",\"pages\":\"Pages 13440-13442\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-10-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1359734524022171\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734524022171","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/22 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Site-specific acetyl modification of 2′-OH of RNA by an oligonucleotide acetylating reagent†
The method for a site-specific RNA acetylation using a novel oligonucleotide acetylating probe (Ac-probe) has been developed. It was confirmed that the acetyl group was site-specifically introduced to a 2′-OH of the sugar part of the target RNA via the formation of the RNA-probe duplex.
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