氧化石墨烯/金属有机框架-235 纳米复合材料修饰的碳糊电极快速检测达卡巴嗪存在下的达奥鲁比星的简单伏安法

IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of the Iranian Chemical Society Pub Date : 2024-09-21 DOI:10.1007/s13738-024-03092-w
Zahra Shamsadin-Azad, Mohammad Ali Taher, Hadi Beitollahi
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引用次数: 0

摘要

本研究利用成功合成的氧化石墨烯(GO)/金属有机框架-235(MOF-235)纳米复合材料构建了一种新颖而简单的电化学传感平台,并将其作为一种优良的改性剂,用于同时测定两种关键抗癌药物达柔比星(DNR)和达卡巴嗪(DTIC)的存在。傅立叶变换红外光谱、能量色散 X 射线光谱、场发射扫描电子显微镜和扫描电子显微镜用于表征 GO/MOF-235 纳米复合材料。利用循环伏安法、差分脉冲伏安法和时变法等电化学方法,深入研究了基于 MOF 和 GO 的改性传感器在磷酸盐缓冲溶液(PBS)(0.1 M-pH7.0)中对 DNR 氧化还原反应的电催化特性。在优化条件下,这种 GO/MOF-235 改性氯化聚乙烯显示出 0.005-400.0 μM 的宽线性响应。检测极限为 0.002 μM。该传感器在 DNR 的 390 mV 和达卡巴嗪(DTIC)的 750 mV 处显示出两个不同的氧化峰(峰电位分离 = 360 mV),从而可以同时检测这两种抗癌药物。利用 GO/MOF-235/CPE 传感器在最后一步有效地检测了样品(DNR 注射液和 DTIC 注射液)中的这些抗癌药物。
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A simple voltammetric method for rapid sensing of daunorubicin in the presence of dacarbazine by graphene oxide/metal–organic framework-235 nanocomposite-modified carbon paste electrode

In the current work, a novel and simple electrochemical sensing platform was built utilizing a graphene oxide (GO)/metal–organic framework-235 (MOF-235) nanocomposite, which was successfully synthesized and used as an excellent modifier to determine the simultaneous presence of two key anticancer medications, daunorubicin (DNR), and dacarbazine (DTIC). Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, field-emission scanning electron microscopy, and scanning electron microscopy (SEM) are used to characterize the GO/MOF-235 nanocomposite. The electrocatalytic properties of the modified sensor based on MOF and GO in phosphate buffer solution (PBS) (0.1 M—pH 7.0) toward DNR redox reaction were thoroughly investigated using electrochemical methodologies including cyclic voltammetry, differential pulse voltammetry, and chronoamperometry. This GO/MOF-235-modified CPE demonstrated a wide linear response of 0.005–400.0 μM under optimized conditions. It was determined that 0.002 μM was the detection limit. This sensor displayed two distinct oxidation peaks at 390 mV for DNR and at 750 mV for dacarbazine (DTIC) (peak potential separation = 360 mV), allowing for the simultaneous detection of the two anticancer medications. Determination of these anticancer medicines in samples (DNR injection and DTIC injection) was effectively accomplished in the final step using the GO/MOF-235/CPE sensor.

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来源期刊
CiteScore
4.40
自引率
8.30%
发文量
230
审稿时长
5.6 months
期刊介绍: JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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