通过 biginelli 反应合成二氢嘧啶酮的最新进展

IF 2.2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of the Iranian Chemical Society Pub Date : 2024-10-04 DOI:10.1007/s13738-024-03100-z

Aqsa Mushtaq, Anza Munawar, Bushra Parveen, Sadia Javed, Ameer Fawad Zahoor, Kulsoom Ghulam Ali, Asim Mansha, Ahmad Irfan

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引用次数: 0

摘要

二氢嘧啶酮骨架（DHMP）在医药化学中占有重要地位，因为其衍生物具有广泛的抗微生物、抗真菌、抗细菌、抗炎和抗癌活性。考虑到 DHPMs 的生物学意义，有机化学家开发了不同的方法来合成这些具有生物活性的目标分子。我们的综述侧重于利用高效催化剂和反应条件，通过 Biginelli 反应一锅合成二氢嘧啶酮，因此涵盖了自 2021 年以来发表的文献。

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Recent advances in the synthesis of dihydropyrimidinones via biginelli reaction

Dihydropyrimidinone skeleton (DHMP) plays a vital part in medicinal and pharmaceutical chemistry as its derivatives exhibit a broad spectrum of anti-microbial, anti-fungal, anti-bacterial, anti-inflammatory and anti-cancer activities. Taking into account the biological significance of DHPMs, organic chemists have developed different methodologies to synthesize these biologically active target molecules. Our review focuses on the one-pot synthesis of dihydropyrimidinones via Biginelli reaction by using the efficient catalysts and reaction conditions, thereby covering the literature published since 2021.

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来源期刊

Journal of the Iranian Chemical Society 化学-化学综合

CiteScore

4.40

自引率

8.30%

发文量

230

审稿时长

5.6 months

期刊介绍： JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.