用于感染性慢性伤口愈合的聚丙烯酰胺混合水凝胶和具有多种粘附性的自组装光动力纳米粒子

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomacromolecules Pub Date : 2024-11-11 Epub Date: 2024-10-21 DOI:10.1021/acs.biomac.4c01162

Tianmeng Kang , Zhaoyuan Guo , Yao Lu , Ju’e Cun , Wenxia Gao , Yuji Pu , Bin He

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引用次数: 0

摘要

对于患者来说，感染伤口的愈合具有挑战性。本文开发了一种具有强组织粘附性、自愈性和无抗生素抗菌性的混合水凝胶，作为促进感染性慢性伤口愈合的敷料。以 N,N-亚甲基双（丙烯酰胺）（BIS）聚合丙烯酰胺（PAM）为基底，在水凝胶基底中分散螯合镁离子（Mg2+）的羧甲基壳聚糖和氯素 e6 自组装纳米粒子（CMCS/Ce6 NPs）。在近红外照射下，CMCS/Ce6 NPs 可通过产生活性氧（ROS）产生良好的光动力抗生素作用。混合水凝胶具有优异的自愈合性能、多种粘附性和生物相容性。体内研究结果表明，混合水凝胶通过 CMCS/Ce6 NPs 的光动力抗生素、Mg2+ 促进细胞增殖、良好的生物粘附性和 PAM 水凝胶的保湿性等综合因素，促进胶原蛋白沉积和血管成熟，从而显著加速伤口愈合。

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Hybrid Hydrogels of Polyacrylamide and Self-assembly Photodynamic Nanoparticles with Diverse Adhesion for Infected Chronic Wound Healing

The healing of infected wounds is challenging for patients. In this paper, a hybrid hydrogel with strong tissue adhesion, self-healing, and antibiosis without antibiotics was developed as a dressing to promote the healing of infected chronic wounds. Acrylamide (PAM) was polymerized with N,N-methylene bis(acrylamide) (BIS) as the substrate, and self-assembled nanoparticles of carboxymethyl chitosan and chlorin e6 (CMCS/Ce6 NPs) trapped with magnesium (Mg²⁺) ions were dispersed in the hydrogel substrate. CMCS/Ce6 NPs provided favorable photodynamic antibiosis via the production of reactive oxygen species (ROS) under NIR irradiation. The hybrid hydrogels exhibited excellent self-healing properties, diverse adhesion, and biocompatibility. The in vivo results indicated that the hybrid hydrogel accelerated wound healing significantly via comprehensive factors of photodynamic antibiosis of CMCS/Ce6 NPs, cell proliferation promotion by Mg²⁺, good bioadhesion, and moisture retention of the PAM hydrogel, which promoted collagen deposition and blood vessel maturation.

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.