用于高效协同化学动力/低温光热抗菌疗法的聚甲醛基水凝胶

IF 4.2 3区 化学 Q2 POLYMER SCIENCE Macromolecular Rapid Communications Pub Date : 2024-10-14 DOI:10.1002/marc.202400415
Haozhe Wang, Dan Li, Qingyao Meng, Xue Li, Kangle Guo, Zehua Zou, Jinsong Peng, Yuan Sun, Tiedong Sun
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引用次数: 0

摘要

伤口表面的细菌感染对人类健康构成了重大威胁,也是临床治疗中的一项艰巨挑战。本研究以聚甲醛为主要成分,明胶和海藻酸钠为结构框架,合成了一种新型抗菌水凝胶。由于 POM 与明胶之间的氢键交联以及海藻酸钠与 Ca2+ 之间的离子交联,这种水凝胶具有优异的机械性能和粘弹性。此外,CuS 纳米粒子的加入还赋予了水凝胶系统光热特性。为了解决对周围正常细胞的潜在热损伤问题,本研究采用了 LT-PTT 结合 CDT 的方法,在增强抗菌功效的同时,尽量减少对健康细胞的意外伤害。研究结果表明,作为一种无机-有机混合材料,基于 POM 的水凝胶将是一种前景广阔的抗菌解决方案,并为非抗生素材料的开发提供了宝贵的见解。
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POM-Based Hydrogels for Efficient Synergistic Chemodynamic/Low-Temperature Photothermal Antibacterial Therapy.

Bacterial infection of wound surfaces has posed a significant threat to human health and represents a formidable challenge in the clinical treatment. In this study, a novel antimicrobial hydrogel utilizing POM is synthesized as the primary component, with gelatin and sodium alginate as the structural framework. The resultant hydrogel demonstrates exceptional mechanical properties and viscoelasticity attributed to the hydrogen-bonded cross-linking between POM and gelatin, as well as the ionic cross-linking between sodium alginate and Ca2+. In addition, the integration of CuS nanoparticles conferred photothermal properties to the hydrogel system. To address the concerns regarding the potential thermal damage to the surrounding normal cells, this study employs a LT-PTT combined with CDT approach to achieve the enhanced antimicrobial efficacy while minimizing the inadvertent harm to the healthy cells. The findings suggested that POM-based hydrogels, serving as an inorganic-organic hybrid material, will represent a promising antimicrobial solution and offer valuable insights for the development of the non-antibiotic materials.

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来源期刊
Macromolecular Rapid Communications
Macromolecular Rapid Communications 工程技术-高分子科学
CiteScore
7.70
自引率
6.50%
发文量
477
审稿时长
1.4 months
期刊介绍: Macromolecular Rapid Communications publishes original research in polymer science, ranging from chemistry and physics of polymers to polymers in materials science and life sciences.
期刊最新文献
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