Inna Blokhina, Andrey Terskov, Arina Evsiukova, Alexander Dubrovsky, Viktoria Adushkina, Daria Zlatogorskaya, Alexander Dmitrenko, Matvey Tuzhilkin, Maria Manzhaeva, Valeria Krupnova, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov, Sergey Popov, Maria Tzoy, Alexander Shirokov, Ivan Fedosov, Oxana Semyachkina-Glushkovskaya
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Photodynamic opening of the blood-brain barrier affects meningeal lymphatics and the brain's drainage in healthy male mice.
Here, we present the new vascular effects of photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA). PDT with 5-ALA induces a leakage of both the meningeal and cerebral blood vessels. The extravasation of photo-excited 5-ALA from the leaky blood vessels into the meninges causes photo-damage of the meningeal lymphatics (MLVs) leading to a dramatic reducing the MLV network and brain's drainage. The PDT-induced impairment of lymphatic regulation of brain's drainage can lead to excessive accumulation of fluids in brain tissues, which is important to consider in the PDT therapy for brain diseases as s possible side effect of PDT with 5-ALA.
期刊介绍:
The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including:
Tissue optics and spectroscopy
Novel microscopies
Optical coherence tomography
Diffuse and fluorescence tomography
Photoacoustic and multimodal imaging
Molecular imaging and therapies
Nanophotonic biosensing
Optical biophysics/photobiology
Microfluidic optical devices
Vision research.