光动力打开血脑屏障会影响健康雄性小鼠的脑膜淋巴管和大脑引流。

IF 2.9 2区 医学 Q2 BIOCHEMICAL RESEARCH METHODS Biomedical optics express Pub Date : 2024-09-26 eCollection Date: 2024-10-01 DOI:10.1364/BOE.527892
Inna Blokhina, Andrey Terskov, Arina Evsiukova, Alexander Dubrovsky, Viktoria Adushkina, Daria Zlatogorskaya, Alexander Dmitrenko, Matvey Tuzhilkin, Maria Manzhaeva, Valeria Krupnova, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov, Sergey Popov, Maria Tzoy, Alexander Shirokov, Ivan Fedosov, Oxana Semyachkina-Glushkovskaya
{"title":"光动力打开血脑屏障会影响健康雄性小鼠的脑膜淋巴管和大脑引流。","authors":"Inna Blokhina, Andrey Terskov, Arina Evsiukova, Alexander Dubrovsky, Viktoria Adushkina, Daria Zlatogorskaya, Alexander Dmitrenko, Matvey Tuzhilkin, Maria Manzhaeva, Valeria Krupnova, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov, Sergey Popov, Maria Tzoy, Alexander Shirokov, Ivan Fedosov, Oxana Semyachkina-Glushkovskaya","doi":"10.1364/BOE.527892","DOIUrl":null,"url":null,"abstract":"<p><p>Here, we present the new vascular effects of photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA). PDT with 5-ALA induces a leakage of both the meningeal and cerebral blood vessels. The extravasation of photo-excited 5-ALA from the leaky blood vessels into the meninges causes photo-damage of the meningeal lymphatics (MLVs) leading to a dramatic reducing the MLV network and brain's drainage. The PDT-induced impairment of lymphatic regulation of brain's drainage can lead to excessive accumulation of fluids in brain tissues, which is important to consider in the PDT therapy for brain diseases as s possible side effect of PDT with 5-ALA.</p>","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 10","pages":"6063-6072"},"PeriodicalIF":2.9000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11482160/pdf/","citationCount":"0","resultStr":"{\"title\":\"Photodynamic opening of the blood-brain barrier affects meningeal lymphatics and the brain's drainage in healthy male mice.\",\"authors\":\"Inna Blokhina, Andrey Terskov, Arina Evsiukova, Alexander Dubrovsky, Viktoria Adushkina, Daria Zlatogorskaya, Alexander Dmitrenko, Matvey Tuzhilkin, Maria Manzhaeva, Valeria Krupnova, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov, Sergey Popov, Maria Tzoy, Alexander Shirokov, Ivan Fedosov, Oxana Semyachkina-Glushkovskaya\",\"doi\":\"10.1364/BOE.527892\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Here, we present the new vascular effects of photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA). PDT with 5-ALA induces a leakage of both the meningeal and cerebral blood vessels. The extravasation of photo-excited 5-ALA from the leaky blood vessels into the meninges causes photo-damage of the meningeal lymphatics (MLVs) leading to a dramatic reducing the MLV network and brain's drainage. The PDT-induced impairment of lymphatic regulation of brain's drainage can lead to excessive accumulation of fluids in brain tissues, which is important to consider in the PDT therapy for brain diseases as s possible side effect of PDT with 5-ALA.</p>\",\"PeriodicalId\":8969,\"journal\":{\"name\":\"Biomedical optics express\",\"volume\":\"15 10\",\"pages\":\"6063-6072\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11482160/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical optics express\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1364/BOE.527892\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical optics express","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1364/BOE.527892","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0

摘要

在这里,我们介绍了 5-aminolevulinic acid(5-ALA)光动力疗法(PDT)对血管的新影响。5-ALA 光动力疗法会导致脑膜和脑血管渗漏。光激发的 5-ALA 从渗漏的血管外渗到脑膜,对脑膜淋巴管(MLV)造成光损伤,导致 MLV 网络和大脑引流急剧减少。光透射疗法引起的脑引流淋巴调节功能障碍会导致脑组织内液体过度积聚,这是用 5-ALA 进行光透射疗法治疗脑部疾病时必须考虑的一个重要问题,也是光透射疗法可能产生的副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Photodynamic opening of the blood-brain barrier affects meningeal lymphatics and the brain's drainage in healthy male mice.

Here, we present the new vascular effects of photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA). PDT with 5-ALA induces a leakage of both the meningeal and cerebral blood vessels. The extravasation of photo-excited 5-ALA from the leaky blood vessels into the meninges causes photo-damage of the meningeal lymphatics (MLVs) leading to a dramatic reducing the MLV network and brain's drainage. The PDT-induced impairment of lymphatic regulation of brain's drainage can lead to excessive accumulation of fluids in brain tissues, which is important to consider in the PDT therapy for brain diseases as s possible side effect of PDT with 5-ALA.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biomedical optics express
Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS
CiteScore
6.80
自引率
11.80%
发文量
633
审稿时长
1 months
期刊介绍: The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.
期刊最新文献
Super resolution reconstruction of fluorescence microscopy images by a convolutional network with physical priors. Physics-guided deep learning-based real-time image reconstruction of Fourier-domain optical coherence tomography. On bench evaluation of intraocular lenses: performance of a commercial interferometer. Predictive coding compressive sensing optical coherence tomography hardware implementation. Development of silicone-based phantoms for biomedical optics from 400 to 1550 nm.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1