甘草提取物对肥胖大鼠肝脏的影响

IF 1.6 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnic & Histochemistry Pub Date : 2024-10-15 DOI:10.1080/10520295.2024.2401159
Ahmet Uyar, Barış Özdere, Turan Yaman, Ahmet Ufuk Kömüroğlu
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引用次数: 0

摘要

我们采用组织病理学和生化方法研究了甘草根提取物对饮食诱发肥胖和高脂血症大鼠的抗肥胖作用。32 只 Wistar 白化大鼠分为四组,每组八只:正常对照组(C)、高脂饮食组(HFD)、高脂饮食 + 甘草组(HFD+M)和正常饮食加甘草组(M)。高脂饮食中脂肪含量为 300 克/千克(4000 千卡/千克);甘草提取物的每日剂量为 1 克/千克体重,采用口胃灌胃法。补充甘草提取物可显著降低因诱导肥胖而导致的体重增加。HFD+M 大鼠肝脏组织学几乎正常,与 HFD 大鼠的退行性变化(包括大泡和小泡脂肪沉积、水肿变性、肝窦扩张和部分肝细胞凝固性坏死)形成鲜明对比,这证明了甘草提取物的保肝作用。甘草提取物可改善血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)、胆固醇(高密度脂蛋白和低密度脂蛋白)和甘油三酯的水平。我们得出的结论是,甘草提取物与高饱和脂肪酸(HFD)一起服用可预防大鼠肥胖并减少肝损伤。
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Effects of licorice root (Glycyrrhiza glabra) extract on the livers of obese rats.

We have investigated anti-obesity effects of the extract of licorice (Glycyrrhiza glabra) root in rats with diet-induced obesity and hyperlipidemia by using histopathological and biochemical methods. Thirty-two Wistar albino rats were divided to four groups of eight: normal control (C), high fat diet (HFD), high fat Diet + Glycyrrhiza glabra (HFD+M), and normal diet with Glycyrrhiza glabra (M). The high fat diet contained 300 g/kg fat (4000 kcal/kg); the daily dosage of Glycyrrhiza glabra extract was 1g/kg body weight by orogastric gavage. Supplementation of Glycyrrhiza glabra extract dramatically reduced increases in body weight caused by the induction of obesity. A hepatoprotective effect of Glycyrrhiza glabra extract was supported by the almost normal histology in the livers of the HFD+M rats, in contrast to the degenerative changes in the HFD rats, which included macrovesicular and microvesicular fat deposits, hydropic degeneration, dilatation of sinusoids and coagulation necrosis of some hepatocytes. Serum levels of alanine transaminase (ALT), aspartic transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), cholesterol (HDL and LDL) and triglycerides, were ameliorated by Glycyrrhiza glabra extract treatment. We conclude that Glycyrrhiza glabra extract given together with HFD could prevent obesity and reduce liver damage in rats.

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来源期刊
Biotechnic & Histochemistry
Biotechnic & Histochemistry 生物-生物工程与应用微生物
CiteScore
3.40
自引率
6.20%
发文量
46
审稿时长
6-12 weeks
期刊介绍: Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.
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