中国云南五种新型蝙蝠冠状病毒的鉴定和遗传特征。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES BMC Veterinary Research Pub Date : 2024-10-12 DOI:10.1186/s12917-024-04310-6
Qian Li, Yutong Hou, Baoyang Huang, Xiang Le, Binghui Wang, Xueshan Xia
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引用次数: 0

摘要

背景:冠状病毒(CoVs)对人类健康构成严重威胁,已成为人类主要的传播性、地方性和致病性病原体;由于它们能够引起传染性疾病,因此是一个重大的健康问题。蝙蝠是多种病毒的天然宿主。CoVs的多次传播和多种新型CoVs在蝙蝠中的发现使人们更加关注蝙蝠作为人畜共患病病毒宿主的能力:本研究对云南省的 61 只蝙蝠进行了分析,共鉴定出 7 种 CoV,包括 3 种具有全基因组序列的 α-CoV 和 2 种 β-CoV。在已鉴定的五种α-CoVs中,四种属于十日咳病毒亚属,一种属于米纳科病毒亚属。基因结构显示,JCC9与HKU10和SARS-CoV-2等已知毒株相似,但也有新发现,如Minunacovirus亚属CoV YJ3c/f和独特的ORF模式。我们的研究结果表明,JCC9株具有独特的重组模式,与果子狸和穿山甲ACE2受体的结合亲和力较高,而HpJC8xc株会在宿主(蝙蝠)之间传播和重组,这表明它有跨越种间屏障感染其他动物的潜在风险:本研究在蝙蝠体内检测到的 CoVs 表现出高度的多样性。基因组分析表明,蝙蝠体内的 CoV 频繁发生重组事件。此外,重组模式和进化分析表明,α-CoVs 更容易在不同蝙蝠科/属之间进行跨物种传播,而 beta-CoVs 则表现出宿主特异性,并倾向于与蝙蝠宿主共同进化。我们的研究结果表明,蝙蝠作为 CoVs 的宿主,应受到持续监控,以防止病毒跨越物种间屏障引起新的感染爆发,进而导致人类或家畜感染病毒性疾病。
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Identification and genetic characterization of five novel bat coronaviruses from Yunnan, China.

Background: Coronaviruses (CoVs) represent a serious threat to human health and have become a major transmissible, endemic, and causative pathogen in humans; they represent a major health concern, given their ability to cause infectious diseases. Bats are natural hosts for diverse viruses. Many transmission events of CoVs and identification of multiple novel CoVs in bats has increased attention towards their capacity to serve as hosts for zoonotic viruses.

Results: In this study, 61 bats from Yunnan Province were analyzed, identifying seven CoVs, including three α- and two β-CoVs with full-genome sequences. Among the five identified alpha-CoVs, four belong to the Decacovirus subgenus and one to the Minunacovirus subgenus. Two beta-CoVs were also identified, both belonging to the Sarbecovirus subgenus.The genetic structures revealed similarities to known strains such as HKU10 and SARS-CoV-2, along with novel findings such as the Minunacovirus subgenus CoV YJ3c/f and unique ORF patterns. Our results demonstrated that strain JCC9 has a unique recombination pattern and shows a higher binding affinity to civet and pangolin ACE2 receptors, then the HpJC8xc strain transmits and recombines between hosts (bats), indicating a potential risk of crossing the interspecies barrier and infecting other animals.

Conclusions: The CoVs detected in the bats studied in this research exhibit high diversity. Genomic analysis revealed that CoVs in bats undergo frequent recombination events. Furthermore, recombination patterns and evolutionary analyses suggest that alpha-CoVs are more prone to cross-species transmission across different bat families/genera, whereas beta-CoVs demonstrate host specificity and tend to co-evolve with their bat hosts.Our finding suggest that bats, as hosts of CoVs, be constantly monitored to prevent outbreaks of new infections caused by viruses passing across interspecies barriers, and consequently, viral diseases in humans or livestock.

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来源期刊
BMC Veterinary Research
BMC Veterinary Research VETERINARY SCIENCES-
CiteScore
4.80
自引率
3.80%
发文量
420
审稿时长
3-6 weeks
期刊介绍: BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
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