精准医疗源于公平代表权。

IF 4.5 2区医学 Q1 HEMATOLOGY Bone Marrow Transplantation Pub Date : 2024-10-21 DOI:10.1038/s41409-024-02430-z

Alexandra Gomez-Arteaga, Nora Chokr, Jeffery J Auletta

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引用次数: 0

摘要

在本期《骨髓移植》特刊中，研究人员报告了 IDH1 [1]、IDH2 [2] 和 FLT3-TKD [3] 可测量残留病（MRD）在造血细胞移植（HCT）前对预测接受异基因 HCT 的成人急性髓性白血病（AML）复发的影响。这些回顾性队列的患者人群反映了临床移植实践模式和研究生物库的参与情况，在每项研究中，非西班牙裔白人（NHW）占84-86%。在这篇评论中，我们探讨了种族和民族差异在获得 HCT 和 HCT 相关研究方面的影响，并提出了促进精准医学代表性的策略，因为该领域正在对 HCT 结果产生影响。

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Precision medicine results from equitable representation.

In this special issue of Bone Marrow Transplantation, investigators report the impact of IDH1 [1], IDH2 [2], and FLT3-TKD [3] measurable residual disease (MRD) pre-hematopoietic cell transplantation (HCT) in predicting relapse of acute myeloid leukemia (AML) in adults receiving allogeneic HCT. The patient population for these retrospective cohorts, reflecting clinical transplant practice patterns and research biobank participation, was 84-86% non-Hispanic White (NHW) in each study. In this commentary, we explore the implications of racial and ethnic disparities in access to both HCT and HCT-related research and propose strategies to promote representation in precision medicine, given the emerging impact of the field on HCT outcomes.

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来源期刊

Bone Marrow Transplantation 医学-免疫学

CiteScore

8.40

自引率

8.30%

发文量

337

审稿时长

6 months

期刊介绍： Bone Marrow Transplantation publishes high quality, peer reviewed original research that addresses all aspects of basic biology and clinical use of haemopoietic stem cell transplantation. The broad scope of the journal thus encompasses topics such as stem cell biology, e.g., kinetics and cytokine control, transplantation immunology e.g., HLA and matching techniques, translational research, and clinical results of specific transplant protocols. Bone Marrow Transplantation publishes 24 issues a year.