血清外泌体小核RNA(snoRNA)特征作为良性和恶性肺结节的预测性生物标记物。

IF 5.3 2区 医学 Q1 ONCOLOGY Cancer Cell International Pub Date : 2024-10-14 DOI:10.1186/s12935-024-03522-y
Fei Cao, Qian You, Feng Zhu, Yu Zhang
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引用次数: 0

摘要

低剂量 CT(LDCT)越来越被认为是检测肺结节的首选方法。然而,要区分结节是良性还是恶性,往往需要反复扫描或进行侵入性组织取样手术。因此,迫切需要无创技术来减少不必要的干预。本研究旨在调查良性和恶性肺结节患者血清中外泌体 snoRNA 的表达谱。我们在血清外泌体中共鉴定出 278 个 snoRNA,发现恶性和良性结节患者的 snoRNA 水平存在显著差异。特别是,通过 qRT-PCR 验证,发现恶性肺结节患者血清中上调的 snoRNA U78 和 U37 显著升高,这两个 snoRNA 有希望成为早期检测肺癌的生物标志物。这项研究强调了血清外泌体 U78 和 U37 作为评估 CT 筛查发现的肺结节风险的重要工具的潜力。
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Serum exosomal small nucleolar RNA (snoRNA) signatures as a predictive biomarker for benign and malignant pulmonary nodules.

Low-dose CT (LDCT) is increasingly recognized as the preferred method for detecting pulmonary nodules. However, distinguishing whether a nodule is benign or malignant often necessitates repeated scans or invasive tissue sampling procedures. Therefore, there is a pressing need for non-invasive techniques to minimize unnecessary interventions. This study aim to investigate the expression profile of exosomal snoRNA in the serum of patients with benign and malignant pulmonary nodules. We identified a total of 278 snoRNAs in serum exosomes, revealing significant differences in snoRNA levels between patients with malignant and benign nodules. Specifically, the upregulated snoRNAs U78 and U37 were validated through qRT-PCR and were found significantly elevated in the serum of patients with malignant pulmonary nodules, positioning them as promising biomarkers for the early detection of lung cancer. This study underscores the potential of serum exosomal U78 and U37 as critical tools for assessing the risk of pulmonary nodules identified through CT screening.

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来源期刊
CiteScore
10.90
自引率
1.70%
发文量
360
审稿时长
1 months
期刊介绍: Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.
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