在不利的环境条件下,丰富的环境能否调节中枢神经系统的表观遗传过程?系统综述。

IF 3.6 4区 医学 Q3 CELL BIOLOGY Cellular and Molecular Neurobiology Pub Date : 2024-10-21 DOI:10.1007/s10571-024-01506-0
Matheus Santos de Sousa Fernandes, Moara Rodrigues Costa, Georgian Badicu, Fatma Hilal Yagin, Gabriela Carvalho Jurema Santos, Jonathan Manoel da Costa, Raphael Fabrício de Souza, Claudia Jacques Lagranha, Luca Paolo Ardigò, Fabrício Oliveira Souto
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引用次数: 0

摘要

本文旨在总结现有文献中关于暴露于富集环境(EE)对不利环境条件下中枢神经系统表观遗传过程的调节作用的证据。我们在三个数据库中进行了搜索:PubMed/Medline(1053 篇文章)、Scopus(121 篇文章)和 Embase(52 篇文章)。在找到的 1226 篇文章中,删除了 173 篇重复文章。在对标题/摘要进行评估后,共排除了 904 篇研究,最终得出 49 篇文章,其中 14 篇被纳入本系统综述。使用不同的无生命物体进行 EE。不良环境条件包括CUMS、败血症、尼古丁暴露、五氯苯酚暴露、早期压力、WAS、高果糖摄入、创伤性脑损伤和七氟烷暴露。在微RNA表达方面,暴露于EE后,在前额叶皮层中观察到miR-221和miR-483的表达增加,而在海马中观察到miR-92a-3p和miR-134的表达减少。在组蛋白修饰方面,海马中的HAT、HDAC/HDAC4、H3(乙酰基K14)、H4(乙酰基K15)、H3K4me3、K3k27me3和HDAC2/3/5都有所减少。在大脑皮层,HDAC2 减少了,而在前额叶皮层,乙酰化的 H3 增加了。在 DNA 修饰方面,海马中的 DNMT 有所减少。本系统综述的结论是,EE 对动物大脑和行为的益处与不同的表观遗传机制直接相关,反映了细胞生长和神经可塑性。EE 可能是一种非药物且易于应用的替代方法,可用于预防影响脑组织的疾病症状。
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Can Environmental Enrichment Modulate Epigenetic Processes in the Central Nervous System Under Adverse Environmental Conditions? A Systematic Review.

The aim of this paper is to summarize the available evidence in the literature regarding the effects generated by exposure to an enriched environment (EE) on the modulation of epigenetic processes in the central nervous system under adverse environmental conditions. Searches were conducted in three databases: PubMed/Medline (1053 articles), Scopus (121 articles), and Embase (52 articles), which were subjected to eligibility criteria. Of the 1226 articles found, 173 duplicates were removed. After evaluating titles/abstracts, 904 studies were excluded, resulting in 49 articles, of which 14 were included in this systematic review. EE was performed using different inanimate objects. Adverse environmental conditions included CUMS, sepsis, nicotine exposure, PCP exposure, early stress, WAS, high fructose intake, TBI, and sevoflurane exposure. Regarding microRNA expression, after exposure to EE, an increase in the expression of miR-221 and miR-483 was observed in the prefrontal cortex, and a reduction in the expression of miR-92a-3p and miR-134 in the hippocampus. Regarding histone modifications, in the hippocampus, there was a reduction of HAT, HDAC/HDAC4, H3 (acetyl K14), H4 (acetyl K15), H3K4me3, K3k27me3, and HDAC2/3/5. In the cortex, there was a reduction of HDAC2, and in the prefrontal cortex, there was an increase in acetylated H3. Regarding DNA modifications, there was a reduction of DNMT in the hippocampus. This systematic review concludes that the benefits of EE on the brain and behavior of animals are directly related to different epigenetic mechanisms, reflecting in cell growth and neuroplasticity. EE may be a non-pharmacological and easy-to-apply alternative to prevent symptoms in disorders affecting brain tissue.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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