关于模拟热量限制以缓解大脑衰老和相关神经退行性病变的临床见解》(Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration)。

IF 3.6 4区 医学 Q3 CELL BIOLOGY Cellular and Molecular Neurobiology Pub Date : 2024-10-16 DOI:10.1007/s10571-024-01493-2
Anchal Trisal, Abhishek Kumar Singh
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引用次数: 0

摘要

衰老是一个不可避免的生理过程,会导致身体机能的逐渐衰退,人们在这一领域进行了大量的研究,试图延缓衰老并减少衰弱的影响。通过对与衰老相关的细胞和分子途径的研究,可以制定治疗策略。其中,热量限制(CR)通过调节胰岛素/IGF-1、mTOR 和 sirtuins 等关键分子靶点,在促进健康老化方面发挥了作用。然而,卡路里限制需要全身心地投入到严格的饮食方案中,这给保持一致性带来了困难。为了绕过繁琐的饮食习惯,热量限制模仿剂(CRMs)通过模仿热量限制的有益效果而成为一种有前途的替代品。这篇综述阐明了雷帕霉素、二甲双胍、白藜芦醇、亚精胺等 CRMs 作为合适的抗衰老分子的分子基础。此外,它还探讨了一些临床试验(从 clinicaltrials.gov 数据库中检索),这些试验旨在证明 CRMs 作为有效候选药物对阿尔茨海默病和帕金森病等与年龄有关的神经退行性疾病的疗效。
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Clinical Insights on Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration.

Aging, an inevitable physiological process leading to a progressive decline in bodily functions, has been an abundantly researched domain with studies attempting to slow it down and reduce its debilitating effects. Investigations into the cellular and molecular pathways associated with aging have allowed the formulation of therapeutic strategies. Of these, caloric restriction (CR) has been implicated for its role in promoting healthy aging by modulating key molecular targets like Insulin/IGF-1, mTOR, and sirtuins. However, CR requires dedication and commitment to a strict regimen which poses a difficulty in maintaining consistency. To maneuver around cumbersome diets, Caloric Restriction Mimetics (CRMs) have emerged as promising alternatives by mimicking the beneficial effects of CR. This review elucidates the molecular foundations enabling CRMs like rapamycin, metformin, resveratrol, spermidine, and many more to function as suitable anti-aging molecules. Moreover, it explores clinical trials (retrieved from the clinicaltrials.gov database) aimed at demonstrating the efficacy of CRMs as effective candidates against age-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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