碳水化合物奖赏的神经和代谢因素:人类口味-营养素学习范例的原理、设计和方法。

IF 2 3区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Contemporary clinical trials Pub Date : 2024-10-15 DOI:10.1016/j.cct.2024.107717
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引用次数: 0

摘要

过度消费超加工食品(UPFs)与不良健康后果有关,是一个日益严重的公共健康问题。超加工食品能迅速提供高生物利用率的卡路里,这可能有助于其强化潜能并推动过度消费。我们的主要目的是测试营养素供应速度对奖赏学习的作用。我们假设,与预测热量供应速度较慢(CS + 慢)或无热量(CS-)的风味饮料相比,预测热量供应速度较快的风味饮料(CS + 快)的奖励相关区域的大脑活动和行为偏好会更大。参与者(n = 64,18-45 岁)将以随机、交叉的顺序饮用 3 种新颖的等甜味饮料,分别含有 110 千卡的蔗糖(CS + 快)、110 千卡的麦芽糊精(CS + 慢)或 0 千卡的蔗糖素蔗糖(CS-),共饮用 6 次。血液代谢物和间接热量测量(包括代谢率和碳水化合物氧化)将在饮用饮料前和饮用饮料后 1 小时内进行评估。对饮料的行为偏好将在前后测试中进行评估。在后测试中,将通过功能磁共振成像评估大脑对每种不含卡路里的口味的反应。这项研究的结果将有助于了解可能导致过度摄入 UPFs 的基本机制。试验注册:clinicaltrials.gov 注册号:NCT06053294。
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Neural and metabolic factors in carbohydrate reward: Rationale, design, and methods for a flavor-nutrient learning paradigm in humans
Overconsumption of ultra-processed foods (UPFs), which are linked with adverse health outcomes, is a growing public health concern. UPFs deliver highly bioavailable calories rapidly, which may contribute to their reinforcing potential and drive overconsumption. Our primary aim is to test the role of speed of nutrient availability on reward learning. We hypothesize that brain activity in reward related areas and behavioral preferences will be greater to a flavored drink predicting rapidly available calories (CS + Fast) compared with a flavored drink predicting more slowly available (CS + Slow) or no (CS-) calories. Participants (n = 64, aged 18–45 years, will consume 3 novel flavored, isosweet beverages containing 110 kcal of sucrose (CS + Fast), 110 kcal of maltodextrin (CS + Slow), or 0-kcal sucralose (CS-) 6 times in randomized, crossover order. Blood metabolites and indirect calorimetry measures, including metabolic rate and carbohydrate oxidation, will be assessed before and for 1 h after beverage consumption. Behavioral preference for beverages will be assessed in a pre- and post-test. Brain response to each flavor without calories will be assessed via functional magnetic resonance imaging in a post-test. Findings from this study will contribute to the understanding of basic mechanisms that may drive overconsumption of UPFs.
Trial registration: clinicaltrials.gov registration #NCT06053294
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来源期刊
CiteScore
3.70
自引率
4.50%
发文量
281
审稿时长
44 days
期刊介绍: Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.
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