败血症中的巨噬细胞活化综合征:从发病机制到临床管理。

IF 4.8 3区 医学 Q2 CELL BIOLOGY Inflammation Research Pub Date : 2024-10-15 DOI:10.1007/s00011-024-01957-7
Shunyao Chen, Cong Zhang, Jialiu Luo, Zhiqiang Lin, Teding Chang, Liming Dong, Deng Chen, Zhao-Hui Tang
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引用次数: 0

摘要

背景:败血症是全球健康和卫生方面的重大挑战。败血症中巨噬细胞的过度活化会导致某些患者表现出类似巨噬细胞活化综合征(MAS)的特征。巨噬细胞活化综合征是一种严重的免疫系统疾病,其特征是体内持续存在严重的炎症。在败血症中,巨噬细胞活化综合征的表现并不典型,因此一些研究人员将其称为巨噬细胞活化样综合征(MALS)。然而,目前还没有针对这种情况的有效治疗措施。本文旨在探讨脓毒症相关 MALS 的潜在治疗方法:本综述旨在综合 MAS 的特定病理生理机制和治疗策略,以探讨脓毒症相关 MALS 的潜在治疗方法:我们检索了主要数据库(包括PubMed、Web of Science和Google Scholar等)中截至2024年3月有关巨噬细胞活化综合征和脓毒症的文献,并结合纳入研究参考文献列表中的研究:我们归纳了脓毒症中巨噬细胞活化综合征的潜在病理生理机制,然后总结了MAS或巨噬细胞活化综合征患者的诊断标准和各种治疗方法的效果。在这两种情况下,相同的治疗方法会产生不同的治疗反应。判断患者是否真正患有 MALS 会对最终疗效产生重大影响。为了解决这一问题,必须开展更多的临床试验和研究工作。
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Macrophage activation syndrome in Sepsis: from pathogenesis to clinical management.

Background: Sepsis represents a significant global health and hygiene challenge. Excessive activation of macrophages in sepsis can result in certain patients displaying characteristics akin to those observed in Macrophage Activation Syndrome (MAS). MAS represents a grave immune system disorder characterized by persistent and severe inflammation within the body. In the context of sepsis, MAS presents atypically, leading some researchers to refer to it as Macrophage Activation-Like Syndrome (MALS). However, there are currently no effective treatment measures for this situation. The purpose of this article is to explore potential treatment methods for sepsis-associated MALS.

Objective: The objective of this review is to synthesize the specific pathophysiological mechanisms and treatment strategies of MAS to investigate potential therapeutic approaches for sepsis-associated MALS.

Method: We searched major databases (including PubMed, Web of Science, and Google Scholar etc.) for literature encompassing macrophage activation syndrome and sepsis up to Mar 2024 and combined with studies found in the reference lists of the included studies.

Conclusion: We have synthesized the underlying pathophysiological mechanism of MALS in sepsis, and then summarized the diagnostic criteria and the effects of various treatment modalities utilized in patients with MAS or MALS. In both scenarios, heterogeneous treatment responses resulting from identical treatment approaches were observed. The determination of whether the patient is genuinely experiencing MALS significantly impacts the ultimate outcomes of therapeutic efficacy. In order to tackle this concern, additional clinical trials and research endeavors are imperative.

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来源期刊
Inflammation Research
Inflammation Research 医学-免疫学
CiteScore
9.90
自引率
1.50%
发文量
134
审稿时长
3-8 weeks
期刊介绍: Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.
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