日本患者 COVID-19 后的症状以及 COVID-19 后诊断出的疾病/病症:利用索赔数据库进行的真实世界研究。

IF 1.9 4区 医学 Q3 INFECTIOUS DISEASES Journal of Infection and Chemotherapy Pub Date : 2024-10-11 DOI:10.1016/j.jiac.2024.10.008
Satoshi Kutsuna, Ryotaro Tajima, Genta Ito, Takuji Komeda, Hideyuki Miyauchi, Yoshitake Kitanishi
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引用次数: 0

摘要

背景:已有 200 多种影响患者生活质量的 COVID-19 后疾病(PCC)症状被报道。本研究描述了知名 PCC 的症状和 COVID-19 诊断后的疾病/病症,并根据日本人口中的流行病浪潮分析了知名 PCC 的趋势:方法:根据性别、出生年份和月份以及病情恶化的风险因素,将日本疾病预防控制中心索赔数据库中确诊为冠状病毒疾病(COVID-19)的患者与未确诊为 COVID-19 的患者(对照组)进行 1:1 配对。2020年1月至2022年3月期间诊断出COVID-19的第一个月为指标月,观察期为2019年7月至指标月起的6个月(患者)和2019年7月至2022年9月(对照组):在配对后的263 456名患者和对照组中,51.8%的患者年龄在18-49岁之间,56.3%为男性,24.5%存在病情加重的风险因素。每 18 名患者中就有 1 人在感染 SARS-CoV-2 2-3 个月后出现知名的 PCC,其中肺血栓栓塞症的几率比(OR)最高(29.37),其次是嗅觉/味觉障碍(13.34)和呼吸衰竭(8.28)。COVID-19 后诊断出的一些常见疾病/病症包括泌尿生殖系统、眼睛和附件、耳和乳突以及某些传染病和寄生虫病。总体而言,从第一波到第六波,风险差异有所减小,但即使在第六波中,大多数症状的 OR 也大于 1.00:结论:随着时间的推移,PCC 症状呈下降趋势,但仍持续存在。医生和患者需要识别 PCC 症状。
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Symptoms of post COVID-19 condition and diseases/conditions diagnosed after COVID-19 in Japanese patients: A real-world study using a claims database.

Background: More than 200 symptoms of post coronavirus disease (COVID-19) condition (PCC) impacting patients' quality of life have been reported. This study describes the symptoms of well-known PCC and diseases/conditions diagnosed after COVID-19 and analyzes the trends in well-known PCC according to the epidemic waves in the Japanese population.

Methods: Patients with a COVID-19 diagnosis in the JMDC claims database were matched 1:1 with individuals without COVID-19 diagnosis (controls) based on sex, year and month of birth, and risk factors for aggravation. The first month of COVID-19 diagnosis from January 2020-March 2022 was the index month, and the observation period was from July 2019 to 6 months from the index month (patients) and July 2019-September 2022 (controls).

Results: Of 263,456 each of patients and controls after matching, 51.8 % were aged 18-49 years, 56.3 % were male, and 24.5 % had risk factors for aggravation. One in 18 patients experienced well-known PCC 2-3 months after severe acute respiratory syndrome cornonavirus 2 infection, with the highest odds ratio (OR) being for pulmonary thromboembolism (29.37), followed by smell/taste disorder (13.34) and respiratory failure (8.28). Some of the common diseases/conditions diagnosed after COVID-19 comprised those of the genitourinary system, eye and adnexa, and ear and mastoid process and certain infectious and parasitic diseases. Overall, the risk difference decreased from the first to the sixth wave, but the OR was >1.00 for most symptoms even during the sixth wave.

Conclusions: PCC symptoms showed a declining trend over time but persisted. Physicians and patients need to recognize PCC symptoms.

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来源期刊
Journal of Infection and Chemotherapy
Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY
CiteScore
4.10
自引率
4.50%
发文量
303
审稿时长
47 days
期刊介绍: The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.
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