间歇性禁食通过自噬激活、减少细胞凋亡和炎症改善老年白化大鼠肾脏由年龄引起的形态变化

IF 2.9 4区 工程技术 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Microscopy and Microanalysis Pub Date : 2025-02-17 DOI:10.1093/mam/ozae102
Rehab Ahmed Rifaai, Nashwa Fathy Gamal El-Tahawy, Samah Mohammed Mahmoud Abozaid, Alzahraa Abdelwahab
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引用次数: 0

摘要

衰老是一个细胞功能逐渐减退的生理过程。肾脏是较易发生老年性组织损伤的器官之一。间歇性禁食对与年龄相关的退行性变化有多种有益影响。本研究旨在探讨间歇性禁食对延缓与年龄相关的肾脏变化可能产生的有益影响,以及这种影响的可能机制。研究人员将 30 只雄性白化大鼠分为三组:对照组,3 个月大的成年大鼠;老年组,15 个月大的大鼠,维持至 18 个月大;间歇性禁食老年组,15 个月大的大鼠,维持间歇性禁食 3 个月。对肾脏进行组织学和免疫组化研究。衰老导致肾功能显著下降,肾小球和肾小管发生明显的退行性变化,组织学结构异常,胶原沉积增加。衰老导致自噬标记物轻链 3 的表达明显减少,活性 Caspase-3 和诱导型一氧化氮合酶的表达增加。间歇性禁食能明显改善这些与年龄相关的肾脏变化。间歇性禁食通过减少与年龄相关的氧化应激、炎症、细胞凋亡和自噬的激活,有效地预防了与年龄相关的肾脏变化。
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Intermittent Fasting Ameliorates Age-Induced Morphological Changes in Aged Albino Rat Kidney via Autophagy Activation and Reduction of Apoptosis and Inflammation.

Aging is a biological process with gradual decrease of cell function. Kidneys are one of the organs with higher susceptibility to the development of age-dependent tissue damage. Intermittent fasting has several beneficial effects on age-related degenerative changes. The aim of this study was to investigate the possible beneficial effect of intermittent fasting in delaying age-related renal changes and the possible mechanisms of this effect. Thirty male albino rats were classified into three groups: control, adult rats aged 3 months; aged group, 15-month-old rats and maintained until the age of 18 months; and intermittent fasting-aged groups, 15-month-old rats maintained on intermittent fasting for 3 months. Kidneys were processed for histological and immunohistochemical study. Aging resulted in a significant reduction in renal function and significant several degenerative changes in renal corpuscles and tubules which showed abnormal histological structure with increased collagen deposition. Aging caused significant reduction in the expression of autophagic marker light chain 3 with increased expression of active caspase-3 and inducible nitric oxide synthase. Intermittent fasting significantly improved these age-related renal changes. Intermittent fasting effectively prevents age-related renal changes through the reduction of age-related oxidative stress, inflammation, apoptosis, and activation of autophagy.

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来源期刊
Microscopy and Microanalysis
Microscopy and Microanalysis 工程技术-材料科学:综合
CiteScore
1.10
自引率
10.70%
发文量
1391
审稿时长
6 months
期刊介绍: Microscopy and Microanalysis publishes original research papers in the fields of microscopy, imaging, and compositional analysis. This distinguished international forum is intended for microscopists in both biology and materials science. The journal provides significant articles that describe new and existing techniques and instrumentation, as well as the applications of these to the imaging and analysis of microstructure. Microscopy and Microanalysis also includes review articles, letters to the editor, and book reviews.
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