纳米医学中的磁性纳米粒子路线图。

IF 2.9 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Nanotechnology Pub Date : 2024-11-05 DOI:10.1088/1361-6528/ad8626
Kai Wu, Jian-Ping Wang, Niranjan A Natekar, Stefano Ciannella, Cristina González-Fernández, Jenifer Gomez-Pastora, Yuping Bao, Jinming Liu, Shuang Liang, Xian Wu, Linh Nguyen T Tran, Karla Mercedes Paz González, Hyeon Choe, Jacob Strayer, Poornima Ramesh Iyer, Jeffrey Chalmers, Vinit Kumar Chugh, Bahareh Rezaei, Shahriar Mostufa, Zhi Wei Tay, Chinmoy Saayujya, Quincy Huynh, Jacob Bryan, Renesmee Kuo, Elaine Yu, Prashant Chandrasekharan, Benjamin Fellows, Steven Conolly, Ravi L Hadimani, Ahmed A El-Gendy, Renata Saha, Thomas J Broomhall, Abigail L Wright, Michael Rotherham, Alicia J El Haj, Zhiyi Wang, Jiarong Liang, Ana Abad-Díaz-de-Cerio, Lucía Gandarias, Alicia G Gubieda, Ana García-Prieto, Mª Luisa Fdez-Gubieda
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引用次数: 0

摘要

磁性纳米粒子(MNPs)是一类直径通常在 1 到 100 纳米之间的小颗粒。这些纳米颗粒由铁、钴、镍等磁性材料或它们的合金组成。MNPs 的纳米级尺寸赋予了它们独特的物理化学(物理和化学)特性,这是其块状对应物所不具备的。它们的多功能性和独特的磁性使其在广泛的科学、医学和技术领域具有重要价值。在过去十年中,基于 MNP 的应用大幅增加,涵盖生物医学用途、环境修复、数据存储、能量存储和催化等领域。鉴于其磁性和小尺寸,MNPs 可通过外部磁场进行操纵和引导。生物医学应用可利用这一特性,将这些纳米粒子导向体内的特定目标,进行成像、药物输送或热疗。本路线图概述了 MNPs 各方面的现状、挑战和进展。它涵盖了磁性能、合成、功能化、表征和生物医学应用,如样品富集、生物测定、成像、热疗、神经调节、组织工程和药物/基因递送。然而,随着 MNPs 在体内应用方面的探索日益增多,有关其细胞毒性、细胞吸收和降解的问题也随之出现,引起了研究人员和临床医生的关注。本路线图旨在提供有关 MNP 研究不断发展的全面视角。
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Roadmap on magnetic nanoparticles in nanomedicine.

Magnetic nanoparticles (MNPs) represent a class of small particles typically with diameters ranging from 1 to 100 nanometers. These nanoparticles are composed of magnetic materials such as iron, cobalt, nickel, or their alloys. The nanoscale size of MNPs gives them unique physicochemical (physical and chemical) properties not found in their bulk counterparts. Their versatile nature and unique magnetic behavior make them valuable in a wide range of scientific, medical, and technological fields. Over the past decade, there has been a significant surge in MNP-based applications spanning biomedical uses, environmental remediation, data storage, energy storage, and catalysis. Given their magnetic nature and small size, MNPs can be manipulated and guided using external magnetic fields. This characteristic is harnessed in biomedical applications, where these nanoparticles can be directed to specific targets in the body for imaging, drug delivery, or hyperthermia treatment. Herein, this roadmap offers an overview of the current status, challenges, and advancements in various facets of MNPs. It covers magnetic properties, synthesis, functionalization, characterization, and biomedical applications such as sample enrichment, bioassays, imaging, hyperthermia, neuromodulation, tissue engineering, and drug/gene delivery. However, as MNPs are increasingly explored forin vivoapplications, concerns have emerged regarding their cytotoxicity, cellular uptake, and degradation, prompting attention from both researchers and clinicians. This roadmap aims to provide a comprehensive perspective on the evolving landscape of MNP research.

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来源期刊
Nanotechnology
Nanotechnology 工程技术-材料科学:综合
CiteScore
7.10
自引率
5.70%
发文量
820
审稿时长
2.5 months
期刊介绍: The journal aims to publish papers at the forefront of nanoscale science and technology and especially those of an interdisciplinary nature. Here, nanotechnology is taken to include the ability to individually address, control, and modify structures, materials and devices with nanometre precision, and the synthesis of such structures into systems of micro- and macroscopic dimensions such as MEMS based devices. It encompasses the understanding of the fundamental physics, chemistry, biology and technology of nanometre-scale objects and how such objects can be used in the areas of computation, sensors, nanostructured materials and nano-biotechnology.
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