Friso M van der Zant, Maurits Wondergem, Wouter A M Broos, Sergiy V Lazarenko, Remco J J Knol
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Differences were evaluated with Mann-Whitney U-tests or two-sample t-tests, when appropriate. P-values ≤0.05 were considered statistically significant.</p><p><strong>Results: </strong>PET/CT showed no adenoma in 163 (22%), adenoma in 451 (62%), hyperplasia/multiglandular disease in 32 (4%), and equivocal results in 83 (11%) patients. A total of 6/729 (1%) adenomas were located intrathyroidally and 16/729 (2%) had an ectopic location. Patients with ectopic/intrathyroidal adenoma showed significantly higher serum PTH levels than patients with no visualization of adenoma on PET. The mean mass of the adenoma was 1 ± 2.3 g in patients with orthotopic adenomas versus 2.7 ± 3.3 g in patients with ectopic/intrathyroidal adenomas; however, this was not significantly different (P = 0.09).</p><p><strong>Conclusion: </strong>In the presented cohort, the frequency of ectopic/intrathyroidal parathyroid adenomas was 3%. 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引用次数: 0
摘要
目的：本文旨在研究转诊接受18F-氟胆碱PET/计算机断层扫描（CT）的患者中异位/甲状旁腺内腺瘤的发生频率和特征：自2015年6月11日至2024年1月15日，共对729名患者进行了研究。记录的患者变量包括甲状旁腺功能亢进类型、性别、年龄、有无症状、肾脏受累情况、骨骼受累情况、甲状旁腺激素（PTH）、血清钙、磷酸盐和维生素 D 以及 24 小时尿钙排泄量。此外，还收集了 PET/CT 结果。如果进行了甲状旁腺切除术，则记录腺瘤的重量。连续变量以平均值 ± SD 表示。差异酌情用曼-惠特尼 U 检验或双样本 t 检验进行评估。P值≤0.05为差异有统计学意义：PET/CT显示无腺瘤患者163例（22%），腺瘤患者451例（62%），增生/多腺疾病患者32例（4%），结果不明确患者83例（11%）。共有6/729（1%）例腺瘤位于甲状腺内，16/729（2%）例腺瘤位于异位。异位/甲状腺内腺瘤患者的血清PTH水平明显高于PET检查未发现腺瘤的患者。正位腺瘤患者的腺瘤平均质量为1 ± 2.3克，而异位/甲状腺内腺瘤患者的腺瘤平均质量为2.7 ± 3.3克，但两者没有明显差异（P = 0.09）：结论：在本研究中，异位/甲状旁腺内腺瘤的发生率为3%。结论：在本报告中，甲状旁腺异位/甲状旁腺内腺瘤的发病率为3%，正位和异位/甲状旁腺内腺瘤的体重无明显差异。
Frequency and characteristics of ectopic parathyroid adenomas in a cohort of patients referred for 18F-fluorocholine PET/CT.
Aim: This article aimed to study the frequency and characteristics of ectopic/intrathyroidal parathyroid adenomas in patients referred for 18F-fluorocholine PET/computed tomography (CT).
Patients and methods: From 11 June 2015 to 15 January 2024, 729 patients were studied. Recorded patient variables included hyperparathyroidism type, sex, age, presence of symptoms, renal involvement, bone involvement, parathyroid hormone (PTH), and serum calcium, phosphate, and vitamin D as well as 24-h urine calcium excretion. PET/CT results were also collected. In case of parathyroidectomy, the weight of the adenomas was recorded. Continuous variables were expressed as mean ± SD. Differences were evaluated with Mann-Whitney U-tests or two-sample t-tests, when appropriate. P-values ≤0.05 were considered statistically significant.
Results: PET/CT showed no adenoma in 163 (22%), adenoma in 451 (62%), hyperplasia/multiglandular disease in 32 (4%), and equivocal results in 83 (11%) patients. A total of 6/729 (1%) adenomas were located intrathyroidally and 16/729 (2%) had an ectopic location. Patients with ectopic/intrathyroidal adenoma showed significantly higher serum PTH levels than patients with no visualization of adenoma on PET. The mean mass of the adenoma was 1 ± 2.3 g in patients with orthotopic adenomas versus 2.7 ± 3.3 g in patients with ectopic/intrathyroidal adenomas; however, this was not significantly different (P = 0.09).
Conclusion: In the presented cohort, the frequency of ectopic/intrathyroidal parathyroid adenomas was 3%. No significant difference in weight was found between orthotopic and ectopic/intrathyroidal parathyroid adenomas.
期刊介绍：
Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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