作物保护行业的数据收集倡议--改善欧洲非饮食风险评估的使命。

IF 3 4区 医学 Q1 MEDICINE, LEGAL Regulatory Toxicology and Pharmacology Pub Date : 2024-10-20 DOI:10.1016/j.yrtph.2024.105727
Neil Morgan , Sarah Adham , Edgars Felkers , Felix M. Kluxen , Christian J. Kuster , Christiane Wiemann
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引用次数: 0

摘要

植物保护产品(PPPs)需要经过严格的安全评估。在欧洲,针对操作人员、工人、旁观者和居民的非饮食风险评估非常保守,因为这一领域的暴露科学历来数据贫乏。欧洲作物生命协会(CLE)旗下各公司已开展合作,生成新数据并汇集现有数据,以完善欧洲食品安全局(EFSA)非饮食暴露指南(2022 年)规定的方法。本文总结了从开发农业操作人员暴露模型 (AOEM) 开始的主要活动,并涵盖了完善旁观者、居民和重新进入工人评估的现有方法的项目,包括旁观者居民果园葡萄园 (BROV) 项目、改进喷洒漂移旁观者和居民暴露评估模型 (BREAM)、完善蒸汽吸入评估的建议,以及可脱落叶面残留 (DFR) 数据的荟萃分析。此外,还介绍了一项对使用封闭式转移系统的益处进行量化的研究、对当前风险评估范例中固有的复合保守性的评估,以及 SeedTROPEX 工作组对新种子处理模型的开发。这些由行业主导的活动强调了非食用接触在购买力平价登记过程中的关键作用,并反映了在确保安全的同时为农民提供有效作物保护解决方案的持续承诺。
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Data collection initiatives of the crop protection industry – A mission to improve non-dietary risk assessment in Europe
Plant protection products (PPPs) undergo rigorous safety assessments. In Europe, non-dietary risk assessments for operators, workers, bystanders and residents are highly conservative as this area of exposure science has historically been data poor. CropLife Europe (CLE) companies have collaborated to generate new data and pool existing data to refine the approaches prescribed by the European Food Safety Authority (EFSA) guidance on non-dietary exposure (2022).
This article summarises key activities, beginning with the development of the Agricultural Operator Exposure Model (AOEM) and covers projects which refine current approaches to bystander, resident and re-entry worker assessment, including the Bystander Resident Orchards Vineyards (BROV) project, improvements to the Bystander and Resident Exposure Assessment Model for spray drift (BREAM), proposals for refined vapour inhalation assessments, and a meta-analysis of Dislodgeable Foliar Residue (DFR) data. A study quantifying the benefits of using closed transfer systems, an appraisal of the inherent compounded conservatism in current risk assessment paradigms and the development of a new seed treatment model by the SeedTROPEX taskforce are also introduced.
These industry-led activities underscore the critical role of non-dietary exposure in the registration process for PPPs and reflect an ongoing commitment to provide farmers with effective crop protection solutions while ensuring safety.
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来源期刊
CiteScore
6.70
自引率
8.80%
发文量
147
审稿时长
58 days
期刊介绍: Regulatory Toxicology and Pharmacology publishes peer reviewed articles that involve the generation, evaluation, and interpretation of experimental animal and human data that are of direct importance and relevance for regulatory authorities with respect to toxicological and pharmacological regulations in society. All peer-reviewed articles that are published should be devoted to improve the protection of human health and environment. Reviews and discussions are welcomed that address legal and/or regulatory decisions with respect to risk assessment and management of toxicological and pharmacological compounds on a scientific basis. It addresses an international readership of scientists, risk assessors and managers, and other professionals active in the field of human and environmental health. Types of peer-reviewed articles published: -Original research articles of relevance for regulatory aspects covering aspects including, but not limited to: 1.Factors influencing human sensitivity 2.Exposure science related to risk assessment 3.Alternative toxicological test methods 4.Frameworks for evaluation and integration of data in regulatory evaluations 5.Harmonization across regulatory agencies 6.Read-across methods and evaluations -Contemporary Reviews on policy related Research issues -Letters to the Editor -Guest Editorials (by Invitation)
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