通过可清除肾脏的 Bi-DTPA 二葡胺进行计算机断层扫描成像,对肝损伤进行无创快速评估。

IF 5.6 1区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Regenerative Biomaterials Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI:10.1093/rb/rbae118
Li Ma, Jinbin Pan, Gang Shu, Haiyan Pan, Jingang Li, Dong Li, Shaokai Sun
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引用次数: 0

摘要

使用碘成像探针的增强计算机断层扫描(CT)成像被广泛用于诊断和评估各种肝脏疾病。然而,这些碘基成像探针面临着难以解决的限制,包括过敏反应和禁忌症。在此,我们首次提出利用肾脏可清除碘的无碘铋螯合物(Bi-DTPA dimeglumine)通过 CT 成像对肝脏缺血再灌注损伤(HIRI)进行无创快速评估。Bi-DTPA 二葡胺具有合成简单、无需纯化、产量接近 100%、可大规模生产(实验室合成量大于 100 克)、生物相容性好和 CT 成像性能优越等优点。在正常大鼠模型中,服用 Bi-DTPA 二葡胺后,肝脏 CT 值在极短的时间内(30 秒)显著增加了 63.79%。此外,在 HIRI 大鼠模型中,根据再灌注后 15 分钟内肝脏 CT 值的显著差异,Bi-DTPA 二葡胺可快速区分健康区域和损伤区域,这与组织病理学分析结果显示出很强的相关性。此外,Bi-DTPA 二葡胺几乎可在 24 小时内通过肾脏排出体外。 作为碘化成像探针的固有替代品,Bi-DTPA 二葡胺在肝病诊断中的应用前景十分广阔。
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Non-invasive fast assessment of hepatic injury through computed tomography imaging with renal-clearable Bi-DTPA dimeglumine.

Enhanced computed tomography (CT) imaging with iodinated imaging probes is widely utilized for the diagnosis and evaluation of various liver diseases. However, these iodine-based imaging probes face intractable limitations including allergic reactions and contraindications. Herein, we propose the utilization of renal-clearable iodine-free bismuth chelate (Bi-DTPA dimeglumine) for the non-invasive fast assessment of hepatic ischemia-reperfusion injury (HIRI) via CT imaging for the first time. Bi-DTPA dimeglumine offers several advantages such as simple synthesis, no purification requirement, a yield approaching 100%, large-scale production capability (laboratory synthesis > 100 g), excellent biocompatibility and superior CT imaging performance. In a normal rat model, the administration of Bi-DTPA dimeglumine resulted in a significant 63.79% increase in liver CT value within a very short time period (30 s). Furthermore, in a HIRI rat model, Bi-DTPA dimeglumine enabled the rapid differentiation between healthy and injured areas based on the notable disparity in liver CT values as early as 15 min post-reperfusion, which showed a strong correlation with the histopathological analysis results. Additionally, Bi-DTPA dimeglumine can be almost eliminated from the body via the kidneys within 24 h. As an inherently advantageous alternative to iodinated imaging probes, Bi-DTPA dimeglumine exhibits promising prospects for application in liver disease diagnosis.

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来源期刊
Regenerative Biomaterials
Regenerative Biomaterials Materials Science-Biomaterials
CiteScore
7.90
自引率
16.40%
发文量
92
审稿时长
10 weeks
期刊介绍: Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.
期刊最新文献
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