Janina Meißner, Niklas Frahm, Michael Hecker, Silvan Elias Langhorst, Pegah Mashhadiakbar, Barbara Streckenbach, Katja Burian, Julia Baldt, Felicita Heidler, Jörg Richter, Uwe Klaus Zettl
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We aimed to use personality tests to explore health-promoting and harmful patient characteristics.</p><p><strong>Objective: </strong>To investigate two important factors influencing the course of MS - the degree of smoking dependence and the status of polypharmacy - in association with personality traits.</p><p><strong>Design: </strong>This is a bicentric, cross-sectional study.</p><p><strong>Methods: </strong>We collected sociodemographic, clinical and medical data from patients with MS (<i>n</i> = 375) at two German neurological clinics. The participants were asked to complete the NEO Five-Factor Inventory (NEO-FFI) and the Temperament and Character Inventory-Revised (TCI-R). Relationships between variables were examined using correlation analyses, and differences between groups were examined using linear models. Current smokers with MS were also asked to complete the Fagerström questionnaire to categorize them into patients with mild, moderate and severe smoking dependence.</p><p><strong>Results: </strong>In our sample, 67.5% were women, and the mean age was 48.1 years. The patients had a median Expanded Disability Status Scale of 3.0 at a median disease duration of 10 years. Patients with MS with severe smoking dependence had on average a significantly higher neuroticism score in the NEO-FFI compared to those with mild or moderate smoking dependence. Patients with MS and polypharmacy had significantly higher neuroticism scores than those without. In the extraversion scale of the NEO-FFI, patients with MS and polypharmacy had significantly lower scores on average. Significant differences were also found when analysing the TCI-R in patients with MS and heavy smoking dependence, with higher scores for harm avoidance (HA) and lower scores for reward dependence, self-directedness (S-D) and cooperativeness (CO) in various subscales. Polypharmacy in patients with MS was associated with higher scores for HA and self-transcendence. Furthermore, patients with polypharmacy showed lower values than patients without polypharmacy in individual subscales of the dimensions of persistence, S-D and CO.</p><p><strong>Conclusion: </strong>Using the NEO-FFI, we were able to show that neuroticism is a detrimental trait and extraversion a protective trait in patients with MS in relation to nicotine dependence and polypharmacy. In addition, the evaluation of the TCI-R showed that high HA as well as low S-D and CO scores were more common in patients with MS and nicotine dependence or polypharmacy. 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引用次数: 0
摘要
背景:对多发性硬化症(MS)的发病和病程影响最大的可改变风险因素是吸烟。此外,吸烟还与患有一种或多种并发症的较高风险有关,并可能导致多重用药。我们的目的是利用人格测试来探索促进健康和有害健康的患者特征:调查影响多发性硬化症病程的两个重要因素--吸烟依赖程度和多药治疗状况--与人格特征的关联:这是一项双中心横断面研究:我们收集了德国两家神经科诊所的多发性硬化症患者(375 人)的社会人口学、临床和医学数据。参与者被要求填写 NEO 五因素量表 (NEO-FFI) 和气质与性格量表-修订版 (TCI-R)。使用相关性分析检验变量之间的关系,使用线性模型检验组间差异。我们还要求目前患有多发性硬化症的吸烟者填写法格斯特伦(Fagerström)问卷,以便将他们分为轻度、中度和重度吸烟依赖患者:在我们的样本中,67.5%为女性,平均年龄为48.1岁。患者的中位残疾状况量表(Expanded Disability Status Scale)为 3.0,中位病程为 10 年。与轻度或中度吸烟依赖的多发性硬化症患者相比,重度吸烟依赖的多发性硬化症患者在NEO-FFI中的神经质平均得分明显更高。合并多种药物治疗的多发性硬化症患者的神经质得分明显高于未合并多种药物治疗的患者。在NEO-FFI的外向性量表中,多发性硬化症和多种药物依赖患者的平均得分明显较低。在分析多发性硬化症和重度吸烟依赖患者的 TCI-R 时也发现了明显的差异,在各分量表中,避免伤害(HA)的得分较高,而奖励依赖、自我导向(S-D)和合作性(CO)的得分较低。多发性硬化症患者的多种药物治疗与较高的 "避免伤害 "和 "自我超越 "得分有关。此外,在持久性、S-D 和 CO 维度的各个分量表中,多药患者的得分低于无多药患者:结论:我们使用 NEO-FFI 分析表明,神经质是多发性硬化症患者的有害特质,而外向性则是与尼古丁依赖和多种药物相关的保护性特质。此外,对 TCI-R 的评估显示,在尼古丁依赖或使用多种药物的多发性硬化症患者中,高 HA 分以及低 S-D 分和 CO 分更为常见。有了这些知识,就可以根据人格特征来了解多种药物和吸烟的风险,并提供有针对性的治疗和咨询。
Personality traits in patients with multiple sclerosis: their association with nicotine dependence and polypharmacy.
Background: The modifiable risk factor exerting the most substantial influence on the development and disease course of multiple sclerosis (MS) is cigarette smoking. Furthermore, smoking is associated with a higher risk of suffering from one or more comorbidities and potentially contributes to polypharmacy. We aimed to use personality tests to explore health-promoting and harmful patient characteristics.
Objective: To investigate two important factors influencing the course of MS - the degree of smoking dependence and the status of polypharmacy - in association with personality traits.
Design: This is a bicentric, cross-sectional study.
Methods: We collected sociodemographic, clinical and medical data from patients with MS (n = 375) at two German neurological clinics. The participants were asked to complete the NEO Five-Factor Inventory (NEO-FFI) and the Temperament and Character Inventory-Revised (TCI-R). Relationships between variables were examined using correlation analyses, and differences between groups were examined using linear models. Current smokers with MS were also asked to complete the Fagerström questionnaire to categorize them into patients with mild, moderate and severe smoking dependence.
Results: In our sample, 67.5% were women, and the mean age was 48.1 years. The patients had a median Expanded Disability Status Scale of 3.0 at a median disease duration of 10 years. Patients with MS with severe smoking dependence had on average a significantly higher neuroticism score in the NEO-FFI compared to those with mild or moderate smoking dependence. Patients with MS and polypharmacy had significantly higher neuroticism scores than those without. In the extraversion scale of the NEO-FFI, patients with MS and polypharmacy had significantly lower scores on average. Significant differences were also found when analysing the TCI-R in patients with MS and heavy smoking dependence, with higher scores for harm avoidance (HA) and lower scores for reward dependence, self-directedness (S-D) and cooperativeness (CO) in various subscales. Polypharmacy in patients with MS was associated with higher scores for HA and self-transcendence. Furthermore, patients with polypharmacy showed lower values than patients without polypharmacy in individual subscales of the dimensions of persistence, S-D and CO.
Conclusion: Using the NEO-FFI, we were able to show that neuroticism is a detrimental trait and extraversion a protective trait in patients with MS in relation to nicotine dependence and polypharmacy. In addition, the evaluation of the TCI-R showed that high HA as well as low S-D and CO scores were more common in patients with MS and nicotine dependence or polypharmacy. With this knowledge, the risk of polypharmacy and smoking can be understood in the context of personality characteristics and targeted treatment and counselling can be provided.
期刊介绍:
Therapeutic Advances in Neurological Disorders is a peer-reviewed, open access journal delivering the highest quality articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of neurology. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in neurology, providing a forum in print and online for publishing the highest quality articles in this area.