Mark P P Lyngbæk, Grit E Legaard, Nina S Nielsen, Cody Durrer, Thomas P Almdal, Morten Asp Vonsild Lund, Benedikte Liebetrau, Caroline Ewertsen, Carsten Lauridsen, Thomas P J Solomon, Kristian Karstoft, Bente K Pedersen, Mathias Ried-Larsen
{"title":"限制热量和不同剂量的运动对 2 型糖尿病患者减脂的影响：DOSE-EX 随机临床试验的二次分析。","authors":"Mark P P Lyngbæk, Grit E Legaard, Nina S Nielsen, Cody Durrer, Thomas P Almdal, Morten Asp Vonsild Lund, Benedikte Liebetrau, Caroline Ewertsen, Carsten Lauridsen, Thomas P J Solomon, Kristian Karstoft, Bente K Pedersen, Mathias Ried-Larsen","doi":"10.1016/j.jshs.2024.100999","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Fat loss mainly conveys the benefits of caloric restriction for people living with type 2 diabetes. The literature is equivocal regarding whether exercise facilitates fat loss during caloric restriction. This analysis aimed to assess the dose-response effects of exercise in combination with a caloric restriction on fat mass (FM) and FM percentage (FM %) in persons with diagnosed type 2 diabetes.</p><p><strong>Methods: </strong>In this secondary analysis of a 4-armed randomized trial, 82 persons living with type 2 diabetes were randomly allocated to the control group (CON) (n = 21), diet control (DCON) (25 % caloric restriction; n = 20), diet control and exercise 3 times per wk (MED) (n = 20), or diet control and exercise 6 times per wk (HED) (n = 21) for 16 wk. The primary analysis was the change in FM% points. Secondary analyses included fat-free mass and visceral adipose tissue (VAT) volume (cm<sup>3</sup>).</p><p><strong>Results: </strong>FM% decreased compared to CON by a mean difference of -3.5% (95% confidence interval (95%CI): -5.6% to -1.4%), -6.3% (95%CI: -8.4% to -4.1%), and -8.0% (95%CI: -10.2% to -5.8%) for DCON, MED, and HED, respectively. Compared to DCON, MED and HED decreased FM% by -2.8% (95%CI: -4.9% to -0.7%) and -4.5% (95%CI: -6.6% to -2.4%), respectively. The difference in FM% between HED and MED was -1.8% (95%CI: -3.9% to 0.4%). DCON and MED decreased fat-free mass compared to CON, whereas HED preserved fat-free mass (-0.2% (95%CI: -2.0% to 1.7%)). Compared to CON, VAT volume decreased by -666.0 cm<sup>3</sup> (95%CI: -912.8 cm<sup>3</sup> to -385.1 cm<sup>3</sup>), -1264.0 (95%CI: -1679.6 cm<sup>3</sup> to -655.9 cm<sup>3</sup>), and -1786.4 cm<sup>3</sup> (95%CI: -2264.6 cm<sup>3</sup> to -1321.2 cm<sup>3</sup>) more for DCON, MED, and HED, respectively. HED decreased VAT volume more than DCON (-1120.4 cm<sup>3</sup> (95%CI: -1746.6 cm<sup>3</sup> to -639.4 cm<sup>3</sup>)) while the remaining comparisons did not reveal any differences.</p><p><strong>Conclusion: </strong>All interventions were superior in reducing FM% compared to standard care. Adding exercise to a caloric restriction was superior in reducing FM% compared to a caloric restriction alone.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"100999"},"PeriodicalIF":9.7000,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of caloric restriction with different doses of exercise on fat loss in people living with type 2 diabetes: A secondary analysis of the DOSE-EX randomized clinical trial.\",\"authors\":\"Mark P P Lyngbæk, Grit E Legaard, Nina S Nielsen, Cody Durrer, Thomas P Almdal, Morten Asp Vonsild Lund, Benedikte Liebetrau, Caroline Ewertsen, Carsten Lauridsen, Thomas P J Solomon, Kristian Karstoft, Bente K Pedersen, Mathias Ried-Larsen\",\"doi\":\"10.1016/j.jshs.2024.100999\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Fat loss mainly conveys the benefits of caloric restriction for people living with type 2 diabetes. The literature is equivocal regarding whether exercise facilitates fat loss during caloric restriction. This analysis aimed to assess the dose-response effects of exercise in combination with a caloric restriction on fat mass (FM) and FM percentage (FM %) in persons with diagnosed type 2 diabetes.</p><p><strong>Methods: </strong>In this secondary analysis of a 4-armed randomized trial, 82 persons living with type 2 diabetes were randomly allocated to the control group (CON) (n = 21), diet control (DCON) (25 % caloric restriction; n = 20), diet control and exercise 3 times per wk (MED) (n = 20), or diet control and exercise 6 times per wk (HED) (n = 21) for 16 wk. The primary analysis was the change in FM% points. Secondary analyses included fat-free mass and visceral adipose tissue (VAT) volume (cm<sup>3</sup>).</p><p><strong>Results: </strong>FM% decreased compared to CON by a mean difference of -3.5% (95% confidence interval (95%CI): -5.6% to -1.4%), -6.3% (95%CI: -8.4% to -4.1%), and -8.0% (95%CI: -10.2% to -5.8%) for DCON, MED, and HED, respectively. Compared to DCON, MED and HED decreased FM% by -2.8% (95%CI: -4.9% to -0.7%) and -4.5% (95%CI: -6.6% to -2.4%), respectively. The difference in FM% between HED and MED was -1.8% (95%CI: -3.9% to 0.4%). DCON and MED decreased fat-free mass compared to CON, whereas HED preserved fat-free mass (-0.2% (95%CI: -2.0% to 1.7%)). Compared to CON, VAT volume decreased by -666.0 cm<sup>3</sup> (95%CI: -912.8 cm<sup>3</sup> to -385.1 cm<sup>3</sup>), -1264.0 (95%CI: -1679.6 cm<sup>3</sup> to -655.9 cm<sup>3</sup>), and -1786.4 cm<sup>3</sup> (95%CI: -2264.6 cm<sup>3</sup> to -1321.2 cm<sup>3</sup>) more for DCON, MED, and HED, respectively. HED decreased VAT volume more than DCON (-1120.4 cm<sup>3</sup> (95%CI: -1746.6 cm<sup>3</sup> to -639.4 cm<sup>3</sup>)) while the remaining comparisons did not reveal any differences.</p><p><strong>Conclusion: </strong>All interventions were superior in reducing FM% compared to standard care. Adding exercise to a caloric restriction was superior in reducing FM% compared to a caloric restriction alone.</p>\",\"PeriodicalId\":48897,\"journal\":{\"name\":\"Journal of Sport and Health Science\",\"volume\":\" \",\"pages\":\"100999\"},\"PeriodicalIF\":9.7000,\"publicationDate\":\"2024-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Sport and Health Science\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jshs.2024.100999\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"HOSPITALITY, LEISURE, SPORT & TOURISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Sport and Health Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jshs.2024.100999","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HOSPITALITY, LEISURE, SPORT & TOURISM","Score":null,"Total":0}
Effects of caloric restriction with different doses of exercise on fat loss in people living with type 2 diabetes: A secondary analysis of the DOSE-EX randomized clinical trial.
Background: Fat loss mainly conveys the benefits of caloric restriction for people living with type 2 diabetes. The literature is equivocal regarding whether exercise facilitates fat loss during caloric restriction. This analysis aimed to assess the dose-response effects of exercise in combination with a caloric restriction on fat mass (FM) and FM percentage (FM %) in persons with diagnosed type 2 diabetes.
Methods: In this secondary analysis of a 4-armed randomized trial, 82 persons living with type 2 diabetes were randomly allocated to the control group (CON) (n = 21), diet control (DCON) (25 % caloric restriction; n = 20), diet control and exercise 3 times per wk (MED) (n = 20), or diet control and exercise 6 times per wk (HED) (n = 21) for 16 wk. The primary analysis was the change in FM% points. Secondary analyses included fat-free mass and visceral adipose tissue (VAT) volume (cm3).
Results: FM% decreased compared to CON by a mean difference of -3.5% (95% confidence interval (95%CI): -5.6% to -1.4%), -6.3% (95%CI: -8.4% to -4.1%), and -8.0% (95%CI: -10.2% to -5.8%) for DCON, MED, and HED, respectively. Compared to DCON, MED and HED decreased FM% by -2.8% (95%CI: -4.9% to -0.7%) and -4.5% (95%CI: -6.6% to -2.4%), respectively. The difference in FM% between HED and MED was -1.8% (95%CI: -3.9% to 0.4%). DCON and MED decreased fat-free mass compared to CON, whereas HED preserved fat-free mass (-0.2% (95%CI: -2.0% to 1.7%)). Compared to CON, VAT volume decreased by -666.0 cm3 (95%CI: -912.8 cm3 to -385.1 cm3), -1264.0 (95%CI: -1679.6 cm3 to -655.9 cm3), and -1786.4 cm3 (95%CI: -2264.6 cm3 to -1321.2 cm3) more for DCON, MED, and HED, respectively. HED decreased VAT volume more than DCON (-1120.4 cm3 (95%CI: -1746.6 cm3 to -639.4 cm3)) while the remaining comparisons did not reveal any differences.
Conclusion: All interventions were superior in reducing FM% compared to standard care. Adding exercise to a caloric restriction was superior in reducing FM% compared to a caloric restriction alone.
期刊介绍：
The Journal of Sport and Health Science (JSHS) is an international, multidisciplinary journal that aims to advance the fields of sport, exercise, physical activity, and health sciences. Published by Elsevier B.V. on behalf of Shanghai University of Sport, JSHS is dedicated to promoting original and impactful research, as well as topical reviews, editorials, opinions, and commentary papers.
With a focus on physical and mental health, injury and disease prevention, traditional Chinese exercise, and human performance, JSHS offers a platform for scholars and researchers to share their findings and contribute to the advancement of these fields. Our journal is peer-reviewed, ensuring that all published works meet the highest academic standards.
Supported by a carefully selected international editorial board, JSHS upholds impeccable integrity and provides an efficient publication platform. We invite submissions from scholars and researchers worldwide, and we are committed to disseminating insightful and influential research in the field of sport and health science.
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