揭示长期血液透析患者接种 COVID-19 mRNA 强化疫苗后独特的效应功能相关批量抗体概况。

IF 4.5 2区 医学 Q2 IMMUNOLOGY Journal of Microbiology Immunology and Infection Pub Date : 2024-10-01 DOI:10.1016/j.jmii.2024.09.007
Chia-Yi Chou, Chung-Yi Cheng, Chih-Hsin Lee, Makoto Kuro-O, Tso-Hsiao Chen, San-Yuan Wang, Yung-Kun Chuang, Yun-Jung Yang, Yun-Hsuan Lin, I-Lin Tsai
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引用次数: 0

摘要

背景:血液透析患者对疫苗接种的反应减弱,疫苗剂量方案也不同。疫苗会诱导抗体,并通过抗体糖基化和效应器功能影响炎症平衡。因此,我们旨在分析接种过严重急性呼吸道综合征冠状病毒 2 疫苗、感染过该病毒或两者兼有的血液透析患者的抗体糖基化谱,并与对照组透析患者的抗体糖基化谱进行比较:将 112 名血液透析患者的血浆样本分为四组:对照组、感染组、接种组和接种后感染组。对接种疫苗的 47 人(接种者)在加强剂量前后的配对血浆样本进行了分析。对四个组别采用相同的分析方法进行横向比较:我们的研究发现,接种组和感染组的 IgG1 肌糖基化都有所下降,而这与促炎生物标志有关。然而,接种疫苗也会导致 IgG 抗体的半乳糖基化和双链化增加,这与抗炎作用和免疫反应的额外调节有关。相比之下,感染导致 IgG2 和 IgA 的岩藻糖基化进一步降低,显示出比接种疫苗更强烈的促炎生物特征:我们的研究结果表明,疫苗接种组和感染组中的岩藻糖基化都具有促炎症生物特征。此外,我们还发现了疫苗接种者中与半乳糖基化相关的进一步调控特征。这些发现表明,针对疫苗接种或感染的抗体调查不应只关注中和作用,还应考虑与效应器功能相关的糖基化谱分析。这些全面的信息对未来疫苗开发的微调很有价值。
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Unveiling unique effector function-related bulk antibody profiles in long-term hemodialysis patients following COVID-19 mRNA booster vaccination.

Background: Hemodialysis patients exhibit a reduced response to vaccination and have different vaccine dose regimens. Vaccines induce antibodies and affect the inflammatory balance through antibody glycosylation and effector functions. Therefore, we aimed to analyze the antibody glycosylation profiles in hemodialysis patients who were vaccinated against severe acute respiratory syndrome coronavirus 2, infected with the virus, or both, and compare them with those of dialysis patients in a control group.

Methods: Plasma samples from 112 hemodialysis patients were assigned to four groups: control, infected, vaccinated, and post-vaccine-infected. Paired plasma samples from 47 people with vaccination (vaccinees) were analyzed before and after the booster dose. The same analytical approach was applied to the four groups for a cross-sectional comparison.

Results: Our study found that both vaccination and infection groups showed decreased fucosylation of IgG1, which is associated with a proinflammatory biosignature. However, vaccination also leads to increased galactosylation and bisection of IgG antibodies, which are associated with anti-inflammatory effects and the additional regulation of immune responses. In contrast, infection led to an additional decrease in the fucosylation of IgG2 and IgA, demonstrating a more intense proinflammatory biosignature than vaccination.

Conclusions: Our findings emphasize the proinflammatory biosignature of afucosylation in both vaccination and infection groups. Additionally, we uncovered further regulated profiles related to galactosylation in vaccinees. These findings suggest that antibody investigation for vaccination or infection should not solely focus on neutralization but should also consider effector function-related glycosylation profiling. This comprehensive information can be valuable for fine-tuning vaccine development in the future.

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来源期刊
Journal of Microbiology Immunology and Infection
Journal of Microbiology Immunology and Infection IMMUNOLOGY-INFECTIOUS DISEASES
CiteScore
15.90
自引率
5.40%
发文量
159
审稿时长
67 days
期刊介绍: Journal of Microbiology Immunology and Infection is an open access journal, committed to disseminating information on the latest trends and advances in microbiology, immunology, infectious diseases and parasitology. Article types considered include perspectives, review articles, original articles, brief reports and correspondence. With the aim of promoting effective and accurate scientific information, an expert panel of referees constitutes the backbone of the peer-review process in evaluating the quality and content of manuscripts submitted for publication.
期刊最新文献
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