n-3 脂肪酸摄入量与老年人手握力和肌肉质量指数的关系：英国生物库横断面研究。

IF 3.9 Experimental gerontology Pub Date : 2024-10-21 DOI:10.1016/j.exger.2024.112612

Abdulrahman T. Alsowail , Marion T. Guerrero Wyss , Frederick K. Ho , Carlos Celis-Morales , Stuart R. Gray

{"title":"n-3 脂肪酸摄入量与老年人手握力和肌肉质量指数的关系：英国生物库横断面研究。","authors":"Abdulrahman T. Alsowail , Marion T. Guerrero Wyss , Frederick K. Ho , Carlos Celis-Morales , Stuart R. Gray","doi":"10.1016/j.exger.2024.112612","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the associations of n-3 fatty acid intake with handgrip strength and muscle mass indices in older adults. A secondary aim was to investigate whether these associations differed by physical activity status.</div></div><div><h3>Research methods & procedures</h3><div>A cross-sectional study included 53,170 participants aged 60 years and over from the UK biobank (25,324 men and 27,846 women). The primary outcomes were grip strength index and muscle mass index, the predictor variable was n-3 fatty acid intake and the covariates were age, ethnicity, Townsend deprivation index, physical activity, multimorbidity count, total energy intake, body fat percentage and the month of assessment. Multivariable linear regression analyses were performed across 5 models. Model 1 was unadjusted; model 2 adjusted for age, ethnicity, deprivation index and month of assessment; model 3 adjusted as in model 2 plus total energy intake; model 4 as in model 2 plus multimorbidity count; and model 5 as in model 4 plus body fat percentage.</div></div><div><h3>Results</h3><div>In model 5, higher n-3 fatty acid intake was positively associated with the grip strength index in women. For each additional gram of n-3 fatty acid consumed per day, there was an increase of 0.03 kg/m<sup>2</sup> (95% CI: 0.00 to 0.06 kg/m<sup>2</sup>) in active women and 0.04 kg/m<sup>2</sup> (95% CI: 0.00 to 0.07 kg/m<sup>2</sup>) in inactive women. However, no significant associations were observed in men, whether active (<em>p</em> = 0.405) or inactive (<em>p</em> = 0.323). Additionally, no significant associations were found between n-3 fatty acid intake and muscle mass index in either active (<em>p</em> = 0.858) or inactive (<em>p</em> = 0.250) men, or in active (<em>p</em> = 0.909) or inactive (<em>p</em> = 0.187) women.</div></div><div><h3>Conclusion</h3><div>Although n-3 fatty acid intake was associated with grip strength index in older women, regardless of their activity status, the magnitude of this association was very small and unlikely to be clinically relevant. Additionally, n-3 fatty acid was not associated with muscle mass index.</div></div>","PeriodicalId":94003,"journal":{"name":"Experimental gerontology","volume":"197 ","pages":"Article 112612"},"PeriodicalIF":3.9000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The associations of n-3 fatty acid intake with handgrip strength and muscle mass indices in older adults: A cross-sectional study from UK Biobank\",\"authors\":\"Abdulrahman T. Alsowail , Marion T. Guerrero Wyss , Frederick K. Ho , Carlos Celis-Morales , Stuart R. Gray\",\"doi\":\"10.1016/j.exger.2024.112612\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>To investigate the associations of n-3 fatty acid intake with handgrip strength and muscle mass indices in older adults. A secondary aim was to investigate whether these associations differed by physical activity status.</div></div><div><h3>Research methods & procedures</h3><div>A cross-sectional study included 53,170 participants aged 60 years and over from the UK biobank (25,324 men and 27,846 women). The primary outcomes were grip strength index and muscle mass index, the predictor variable was n-3 fatty acid intake and the covariates were age, ethnicity, Townsend deprivation index, physical activity, multimorbidity count, total energy intake, body fat percentage and the month of assessment. Multivariable linear regression analyses were performed across 5 models. Model 1 was unadjusted; model 2 adjusted for age, ethnicity, deprivation index and month of assessment; model 3 adjusted as in model 2 plus total energy intake; model 4 as in model 2 plus multimorbidity count; and model 5 as in model 4 plus body fat percentage.</div></div><div><h3>Results</h3><div>In model 5, higher n-3 fatty acid intake was positively associated with the grip strength index in women. For each additional gram of n-3 fatty acid consumed per day, there was an increase of 0.03 kg/m<sup>2</sup> (95% CI: 0.00 to 0.06 kg/m<sup>2</sup>) in active women and 0.04 kg/m<sup>2</sup> (95% CI: 0.00 to 0.07 kg/m<sup>2</sup>) in inactive women. However, no significant associations were observed in men, whether active (<em>p</em> = 0.405) or inactive (<em>p</em> = 0.323). Additionally, no significant associations were found between n-3 fatty acid intake and muscle mass index in either active (<em>p</em> = 0.858) or inactive (<em>p</em> = 0.250) men, or in active (<em>p</em> = 0.909) or inactive (<em>p</em> = 0.187) women.</div></div><div><h3>Conclusion</h3><div>Although n-3 fatty acid intake was associated with grip strength index in older women, regardless of their activity status, the magnitude of this association was very small and unlikely to be clinically relevant. Additionally, n-3 fatty acid was not associated with muscle mass index.</div></div>\",\"PeriodicalId\":94003,\"journal\":{\"name\":\"Experimental gerontology\",\"volume\":\"197 \",\"pages\":\"Article 112612\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2024-10-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental gerontology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0531556524002584\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental gerontology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0531556524002584","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

研究目的调查 n-3 脂肪酸摄入量与老年人手握力和肌肉质量指数之间的关系。次要目的是调查这些关联是否因体力活动状况而异：这项横断面研究纳入了英国生物库中 53170 名 60 岁及以上的参与者（男性 25324 人，女性 27846 人）。主要结果为握力指数和肌肉质量指数，预测变量为 n-3 脂肪酸摄入量，协变量为年龄、种族、汤森贫困指数、体力活动、多病症计数、总能量摄入量、体脂百分比和评估月份。在 5 个模型中进行了多变量线性回归分析。模型 1 未经调整；模型 2 对年龄、种族、贫困指数和评估月份进行了调整；模型 3 的调整与模型 2 相同，外加总能量摄入；模型 4 与模型 2 相同，外加多病症计数；模型 5 与模型 4 相同，外加体脂百分比：结果：在模型 5 中，女性较高的 n-3 脂肪酸摄入量与握力指数呈正相关。每天每多摄入 1 克 n-3 脂肪酸，活跃女性的握力指数就会增加 0.03 kg/m2（95% CI：0.00 至 0.06 kg/m2），而不活跃女性的握力指数则会增加 0.04 kg/m2（95% CI：0.00 至 0.07 kg/m2）。然而，在男性中，无论是活跃期（p = 0.405）还是非活跃期（p = 0.323），都没有观察到明显的相关性。此外，在活跃（p = 0.858）或不活跃（p = 0.250）的男性中，或在活跃（p = 0.909）或不活跃（p = 0.187）的女性中，n-3 脂肪酸摄入量与肌肉质量指数之间均未发现明显关联：结论：虽然 n-3 脂肪酸的摄入量与老年妇女的握力指数有关，与她们的活动状况无关，但这种关联的程度非常小，不太可能与临床相关。此外，n-3 脂肪酸与肌肉质量指数无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

The associations of n-3 fatty acid intake with handgrip strength and muscle mass indices in older adults: A cross-sectional study from UK Biobank

Objectives

To investigate the associations of n-3 fatty acid intake with handgrip strength and muscle mass indices in older adults. A secondary aim was to investigate whether these associations differed by physical activity status.

Research methods & procedures

A cross-sectional study included 53,170 participants aged 60 years and over from the UK biobank (25,324 men and 27,846 women). The primary outcomes were grip strength index and muscle mass index, the predictor variable was n-3 fatty acid intake and the covariates were age, ethnicity, Townsend deprivation index, physical activity, multimorbidity count, total energy intake, body fat percentage and the month of assessment. Multivariable linear regression analyses were performed across 5 models. Model 1 was unadjusted; model 2 adjusted for age, ethnicity, deprivation index and month of assessment; model 3 adjusted as in model 2 plus total energy intake; model 4 as in model 2 plus multimorbidity count; and model 5 as in model 4 plus body fat percentage.

Results

In model 5, higher n-3 fatty acid intake was positively associated with the grip strength index in women. For each additional gram of n-3 fatty acid consumed per day, there was an increase of 0.03 kg/m² (95% CI: 0.00 to 0.06 kg/m²) in active women and 0.04 kg/m² (95% CI: 0.00 to 0.07 kg/m²) in inactive women. However, no significant associations were observed in men, whether active (p = 0.405) or inactive (p = 0.323). Additionally, no significant associations were found between n-3 fatty acid intake and muscle mass index in either active (p = 0.858) or inactive (p = 0.250) men, or in active (p = 0.909) or inactive (p = 0.187) women.

Conclusion

Although n-3 fatty acid intake was associated with grip strength index in older women, regardless of their activity status, the magnitude of this association was very small and unlikely to be clinically relevant. Additionally, n-3 fatty acid was not associated with muscle mass index.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊