聚苯乙烯纳米塑料通过吸附血浆蛋白促进血栓形成。

Chao Sheng, Guozhen Wang, Zijia Liu, Yuchen Zheng, Zijie Zhao, Duo Tang, Wenzhuo Li, Ao Li, Qi Zong, Renhang Zhou, Xiaonan Hou, Mengfei Yao, Zhixiang Zhou
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引用次数: 0

摘要

塑料产品为现代生活提供了极大的便利。然而,人们越来越关注塑料分解过程中形成的纳米塑料对健康造成的潜在危害。目前,人们对纳米塑料的生物效应和机理还缺乏深入研究。在本研究中,我们报告了聚苯乙烯纳米塑料可进入血液并促进血栓形成。我们的研究结果表明,聚苯乙烯纳米塑料吸附血浆蛋白,尤其是凝血因子 XII 和纤溶酶原激活剂抑制剂-1,在这一过程中发挥了关键作用,这一点已通过蛋白质组学、生物信息学分析和分子动力学模拟得到证实。纳米塑料对这些蛋白质的吸附是增强血栓形成的一个重要因素。这种新发现的导致血栓形成增强的蛋白质吸附途径为了解纳米塑料的生物效应提供了新的视角,可为未来塑料的安全和环境风险评估提供参考。
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Polystyrene nanoplastics enhance thrombosis through adsorption of plasma proteins.

Plastic products offer remarkable convenience for modern life. However, growing concerns are emerging regarding the potential health hazards posed by nanoplastics, which formed as plastics break down. Currently, the biological effects and mechanisms induced by nanoplastics are largely underexplored. In this study, we report that polystyrene nanoplastics can enter the bloodstream and enhance thrombus formation. Our findings show that polystyrene nanoplastics adsorb plasma proteins, particularly coagulation factor XII and plasminogen activator inhibitor-1, play a key role in this process, as demonstrated by proteomics, bioinformatic analyses, and molecular dynamics simulations. The adsorption of these proteins by nanoplastics is an essential factor in thrombosis enhancement. This newly uncovered pathway of protein adsorption leading to enhanced thrombosis provides new insights into the biological effects of nanoplastics, which may inform future safety and environmental risk assessment of plastics.

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