{"title":"Deacetylative Cyanation: A Cyanide-Free Route to Thiocyanates and Cyanamides","authors":"Si Yeon Kim, Hee Nam Lim","doi":"10.1039/d4cc04539d","DOIUrl":null,"url":null,"abstract":"The use of N-hydroxy-2-oxopropanimidoyl chloride as a latent cyanide transfer agent is reported. This easy-to-handle, scalable, and operationally simple agent can be installed on common nucleophiles, including thiols and secondary amines, affording synthetically useful thiocyanates and cyanamides. This method complements conventional approaches that use poisonous and volatile cyanogen halides.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4cc04539d","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Deacetylative Cyanation: A Cyanide-Free Route to Thiocyanates and Cyanamides
The use of N-hydroxy-2-oxopropanimidoyl chloride as a latent cyanide transfer agent is reported. This easy-to-handle, scalable, and operationally simple agent can be installed on common nucleophiles, including thiols and secondary amines, affording synthetically useful thiocyanates and cyanamides. This method complements conventional approaches that use poisonous and volatile cyanogen halides.
期刊介绍:
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.