皮肤伤口愈合中的单细胞测序技术

IF 6.3 1区 医学 Q1 DERMATOLOGY Burns & Trauma Pub Date : 2024-10-23 DOI:10.1093/burnst/tkae043
Xu Cheng Cheng, Wang Zi Tong, Wang Rui, Zhao Feng, Hou Shuai, Wang Zhe
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引用次数: 0

摘要

皮肤伤口愈合是一个复杂的生物过程,主要发生在受伤、烧伤或糖尿病溃疡时。皮炎和黑色素瘤诱发的皮肤癌等其他疾病也会引发皮肤伤口愈合。皮肤损伤后延迟愈合或不愈合是一个重要的临床问题;因此,有必要从细胞和分子水平进一步探索伤口愈合的发生和发展。单细胞测序(SCS)用于对单个细胞的遗传信息进行测序和分析。此外,SCS 还能准确检测细胞表达和基因序列。单细胞测序技术的使用产生了有关伤口愈合的新概念,使其成为研究相关机制和制定治疗策略的重要工具。本文将讨论 SCS 技术的应用价值、最新研究对皮肤伤口愈合的影响以及 SCS 技术在临床应用中的价值。利用 SCS 确定伤口修复的潜在生物标志物将有助于加速伤口愈合、减少疤痕形成、优化给药和促进个性化治疗。
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Single-cell sequencing technology in skin wound healing
Skin wound healing is a complicated biological process that mainly occurs in response to injury, burns, or diabetic ulcers. It can also be triggered by other conditions such as dermatitis and melanoma-induced skin cancer. Delayed healing or non-healing after skin injury presents an important clinical issue; therefore, further explorations into the occurrence and development of wound healing at the cellular and molecular levels are necessary. Single-cell sequencing (SCS) is used to sequence and analyze the genetic messages of a single cell. Furthermore, SCS can accurately detect cell expression and gene sequences. The use of SCS technology has resulted in the emergence of new concepts pertaining to wound healing, making it an important tool for studying the relevant mechanisms and developing treatment strategies. This article discusses the application value of SCS technology, the effects of the latest research on skin wound healing, and the value of SCS technology in clinical applications. Using SCS to determine potential biomarkers for wound repair will serve to accelerate wound healing, reduce scar formation, optimize drug delivery, and facilitate personalized treatments.
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来源期刊
Burns & Trauma
Burns & Trauma 医学-皮肤病学
CiteScore
8.40
自引率
9.40%
发文量
186
审稿时长
6 weeks
期刊介绍: The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.
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