应激颗粒和细胞器:协调健康和疾病中的细胞反应

IF 13.6 1区 生物学 Q1 CELL BIOLOGY Protein & Cell Pub Date : 2024-10-23 DOI:10.1093/procel/pwae057
Ying Liu,Yin Li,Peipei Zhang
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引用次数: 0

摘要

有膜细胞器和无膜细胞器(MLO)协调真核细胞内的各种生物过程。其中,应激颗粒(SGs)是一种重要的细胞质 MLOs,在细胞应激时形成,具有类似液体的特性和稳定的亚结构。应激颗粒与多种细胞器相互作用,从而影响对健康和疾病都至关重要的细胞通路。本综述讨论了 SG 与细胞器之间的相互作用,并探讨了用于分析 SG 与其他 MLO 之间相互作用的方法。此外,它还强调了 SG 在调节细胞反应和 ALS 发病机制中的关键作用。深入了解这些相互作用对于破译生理过程和病理状况的内在机制至关重要。
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Stress granules and organelles: Coordinating cellular responses in health and disease.
Membrane-bound organelles and membraneless organelles (MLOs) coordinate various biological processes within eukaryotic cells. Among these, stress granules (SGs) are significant cytoplasmic MLOs that form in response to cellular stress, exhibiting liquid-like properties alongside stable substructures. SGs interact with diverse organelles, thereby influencing cellular pathways that are critical in both health and disease contexts. This review discusses the interplay between SGs and organelles and explores the methodologies employed to analyze interactions between SGs and other MLOs. Furthermore, it highlights the pivotal roles SGs play in regulating cellular responses and the pathogenesis of ALS. Gaining insights into these interactions is essential for deciphering the mechanisms underlying both physiological processes and pathological conditions.
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来源期刊
Protein & Cell
Protein & Cell CELL BIOLOGY-
CiteScore
24.00
自引率
0.90%
发文量
1029
审稿时长
6-12 weeks
期刊介绍: Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.
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