{"title":"TMEM63B 在膜结构发生变化时扰乱磷脂","authors":"","doi":"10.1038/s41594-024-01421-4","DOIUrl":null,"url":null,"abstract":"Phospholipid distribution across the lipid bilayer of plasma membranes is critical for various cellular functions. A genome-wide screen and structural analysis identified TMEM63B as a membrane structure-responsive lipid scramblase. In response to changes in membrane structure, TMEM63B alters its conformation and translocates phospholipids, thereby controlling plasma membrane lipid distribution.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"14 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"TMEM63B scrambles phospholipids in response to changes in membrane structure\",\"authors\":\"\",\"doi\":\"10.1038/s41594-024-01421-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Phospholipid distribution across the lipid bilayer of plasma membranes is critical for various cellular functions. A genome-wide screen and structural analysis identified TMEM63B as a membrane structure-responsive lipid scramblase. In response to changes in membrane structure, TMEM63B alters its conformation and translocates phospholipids, thereby controlling plasma membrane lipid distribution.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"14 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-024-01421-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-024-01421-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
TMEM63B scrambles phospholipids in response to changes in membrane structure
Phospholipid distribution across the lipid bilayer of plasma membranes is critical for various cellular functions. A genome-wide screen and structural analysis identified TMEM63B as a membrane structure-responsive lipid scramblase. In response to changes in membrane structure, TMEM63B alters its conformation and translocates phospholipids, thereby controlling plasma membrane lipid distribution.
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