{"title":"NALIRIFOX 在转移性胰腺癌一线治疗中的应用:NAPOLI 3 之外的证据","authors":"Zev A. Wainberg, Eileen M. O’Reilly","doi":"10.1038/s41571-024-00952-5","DOIUrl":null,"url":null,"abstract":"<p>We read with interest the News & Views article by Nevala-Plagemann and Garrido-Laguna (Nevala-Plagemann, C. & Garrido-Laguna, I. NALIRIFOX for metastatic pancreatic adenocarcinoma: hope or hype? <i>Nat. Rev. Clin. Oncol</i>. <b>21</b>, 567–568 (2024))<sup>1</sup>. In this article, the authors question whether the addition of nanoliposomal irinotecan, 5-fluorouracil, leucovorin and oxaliplatin (NALIRIFOX) to therapeutic options constitutes true progress for patients with metastatic pancreatic ductal adenocarcinoma (mPDAC).</p>","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":81.1000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"NALIRIFOX in the frontline for metastatic pancreatic cancer: evidence beyond NAPOLI 3\",\"authors\":\"Zev A. Wainberg, Eileen M. O’Reilly\",\"doi\":\"10.1038/s41571-024-00952-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>We read with interest the News & Views article by Nevala-Plagemann and Garrido-Laguna (Nevala-Plagemann, C. & Garrido-Laguna, I. NALIRIFOX for metastatic pancreatic adenocarcinoma: hope or hype? <i>Nat. Rev. Clin. Oncol</i>. <b>21</b>, 567–568 (2024))<sup>1</sup>. In this article, the authors question whether the addition of nanoliposomal irinotecan, 5-fluorouracil, leucovorin and oxaliplatin (NALIRIFOX) to therapeutic options constitutes true progress for patients with metastatic pancreatic ductal adenocarcinoma (mPDAC).</p>\",\"PeriodicalId\":19079,\"journal\":{\"name\":\"Nature Reviews Clinical Oncology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":81.1000,\"publicationDate\":\"2024-10-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Clinical Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41571-024-00952-5\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Clinical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41571-024-00952-5","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
我们饶有兴趣地阅读了 Nevala-Plagemann 和 Garrido-Laguna 撰写的《新闻与观点》(Nevala-Plagemann, C. & Garrido-Laguna, I. NALIRIFOX 治疗转移性胰腺腺癌:希望还是炒作?Nat.Rev. Clin.Oncol.21, 567-568 (2024))1.在这篇文章中,作者对纳米脂质体伊立替康、5-氟尿嘧啶、亮菌素和奥沙利铂(NALIRIFOX)的加入是否构成转移性胰腺导管腺癌(mPDAC)患者治疗方案的真正进展提出了质疑。
NALIRIFOX in the frontline for metastatic pancreatic cancer: evidence beyond NAPOLI 3
We read with interest the News & Views article by Nevala-Plagemann and Garrido-Laguna (Nevala-Plagemann, C. & Garrido-Laguna, I. NALIRIFOX for metastatic pancreatic adenocarcinoma: hope or hype? Nat. Rev. Clin. Oncol. 21, 567–568 (2024))1. In this article, the authors question whether the addition of nanoliposomal irinotecan, 5-fluorouracil, leucovorin and oxaliplatin (NALIRIFOX) to therapeutic options constitutes true progress for patients with metastatic pancreatic ductal adenocarcinoma (mPDAC).
期刊介绍:
Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.