从微环境动力学和分子洞察到生物标记分析和治疗模式,解密三阴性乳腺癌的全貌。

IF 10.9 1区 医学 Q1 CHEMISTRY, MEDICINAL Medicinal Research Reviews Pub Date : 2024-10-24 DOI:10.1002/med.22090
Harshita Tiwari, Swati Singh, Sonal Sharma, Priyamvada Gupta, Ashish Verma, Amrit Chattopadhaya, Brijesh Kumar, Sakshi Agarwal, Rajiv Kumar, Sanjeev Kumar Gupta, Vibhav Gautam
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引用次数: 0

摘要

三阴性乳腺癌(TNBC)因其侵袭性而成为临床肿瘤学中的一个显著挑战,这是因为它缺乏孕激素受体(PR)、雌激素受体(ER)和人类表皮生长因子受体(HER-2)。TNBC 的异质肿瘤微环境(TME)由多种成分组成,它们错综复杂地相互作用,逃避免疫反应,促进癌症进展和转移。根据分子基因表达,TNBC 可分为四种分子亚型:基底样(BL1 和 BL2)、腔内雄激素受体(LAR)、免疫调节(IM)和间质。TNBC 是一种侵袭性组织学变异,预后不良,治疗反应差。大多数 TNBC 患者缺乏反应可归因于疾病的异质性,这突出表明需要更有效的治疗方法和可靠的预后生物标志物。靶向某些信号通路及其成分已成为一种有希望改善患者预后的治疗策略。在这篇综述中,我们总结了 TNBC 中动态 TME 各组成部分之间的相互作用,并讨论了其分子亚型的分类。此外,本综述的目的还在于汇编和概述最近发现的新型 TNBC 生物标记物和靶向治疗药物的最新数据,这些药物已被证明能成功治疗转移性 TNBC。化疗免疫疗法、基于嵌合抗原受体(CAR)-T细胞的免疫疗法、植物代谢物介导的自然疗法、光动力疗法和光热疗法等新型治疗策略的出现产生了重大的积极影响,为更有效的干预措施铺平了道路。
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Deciphering the landscape of triple negative breast cancer from microenvironment dynamics and molecular insights to biomarker analysis and therapeutic modalities.

Triple negative breast cancer (TNBC) displays a notable challenge in clinical oncology due to its invasive nature which is attributed to the absence of progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor (HER-2). The heterogenous tumor microenvironment (TME) of TNBC is composed of diverse constituents that intricately interact to evade immune response and facilitate cancer progression and metastasis. Based on molecular gene expression, TNBC is classified into four molecular subtypes: basal-like (BL1 and BL2), luminal androgen receptor (LAR), immunomodulatory (IM), and mesenchymal. TNBC is an aggressive histological variant with adverse prognosis and poor therapeutic response. The lack of response in most of the TNBC patients could be attributed to the heterogeneity of the disease, highlighting the need for more effective treatments and reliable prognostic biomarkers. Targeting certain signaling pathways and their components has emerged as a promising therapeutic strategy for improving patient outcomes. In this review, we have summarized the interactions among various components of the dynamic TME in TNBC and discussed the classification of its molecular subtypes. Moreover, the purpose of this review is to compile and provide an overview of the most recent data about recently discovered novel TNBC biomarkers and targeted therapeutics that have proven successful in treating metastatic TNBC. The emergence of novel therapeutic strategies such as chemoimmunotherapy, chimeric antigen receptor (CAR)-T cells-based immunotherapy, phytometabolites-mediated natural therapy, photodynamic and photothermal approaches have made a significant positive impact and have paved the way for more effective interventions.

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来源期刊
CiteScore
29.30
自引率
0.00%
发文量
52
审稿时长
2 months
期刊介绍: Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.
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Deciphering the landscape of triple negative breast cancer from microenvironment dynamics and molecular insights to biomarker analysis and therapeutic modalities. Issue Information Front Cover Image, Volume 44, Issue 6 Inside Front Cover Image, Volume 44, Issue 6 An overview of the progress made in research into the Mpox virus.
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