复发性妊娠失败后的自身免疫疾病诊断。

IF 2.5 3区 医学 Q3 IMMUNOLOGY American Journal of Reproductive Immunology Pub Date : 2024-10-26 DOI:10.1111/aji.70006
Marisa R. Imbroane, Felicia LeMoine, Kelly S. Gibson
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引用次数: 0

摘要

问题研究表明,反复妊娠失败(RPL)与细胞介导的免疫失调之间存在联系。我们旨在确定RPL病史是否与细胞介导的自身免疫性疾病(AIC)的诊断有关:研究方法:我们利用 TriNetX 研究网络进行了一项回顾性队列研究。RPL组有≥3次自然流产或漏流产。对照组至少有一次妊娠,但未确诊为 RPL。对年龄、种族和民族采用倾向得分匹配法。Z检验和相对风险分析研究了RPL与随后的AIC诊断之间的关系:每个队列共纳入 12.8376 万名患者。RPL与AIC综合征(RR 1.60,95% CI [1.51,1.69])、克罗恩病、格雷夫斯病、桥本氏甲状腺炎、多发性硬化症、类风湿性关节炎、Sjogren综合征、系统性红斑狼疮和溃疡性结肠炎的风险增加有关,但与银屑病关节炎无关:通过使用一个大型的 RPL 患者研究数据库,我们能够证明 RPL 的先兆诊断与 AIC 的后续诊断风险增加有关,这种风险通常发生在 RPL 后的 1 到 10 年之间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Autoimmune Condition Diagnosis Following Recurrent Pregnancy Loss

Problem

Research has suggested a link between recurrent pregnancy loss (RPL) and cell-mediated immunity dysregulation. We aimed to determine if a history of RPL is associated with diagnosis of a cell-mediated autoimmune condition (AIC).

Method of Study

A retrospective cohort study was conducted using the TriNetX research network. The RPL group had ≥3 spontaneous or missed abortions. Controls had at least one pregnancy but no diagnosis of RPL. Propensity score matching was used for age, race, and ethnicity. Z-test and relative risk analysis investigated the relationship between RPL and subsequent AIC diagnoses.

Results

One hundred twenty-eight thousand three hundred seventy-six patients were included in each cohort. RPL was associated with an increased risk for an AIC composite (RR 1.60, 95% CI [1.51, 1.69]), Crohn's disease, Graves’ disease, Hashimoto's thyroiditis, multiple sclerosis, rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, and ulcerative colitis, but not psoriatic arthritis.

Conclusions

Using a large research database of patients with RPL, we were able to demonstrate that an antecedent diagnosis of RPL is associated with increased risk of subsequent diagnosis of an AIC, often between 1 and 10 years after RPL.

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来源期刊
CiteScore
6.20
自引率
5.60%
发文量
314
审稿时长
2 months
期刊介绍: The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.
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