白内障形成过程中的氧化应激:是否有一种治疗方法即将问世?

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants Pub Date : 2024-10-16 DOI:10.3390/antiox13101249
Jingyan Li, Francesco Buonfiglio, Ying Zeng, Norbert Pfeiffer, Adrian Gericke
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引用次数: 0

摘要

白内障是全球失明的主要原因之一,与氧化应激引起的晶状体上皮细胞(LEC)损伤密切相关。导致白内障形成的主要因素包括衰老、动脉高血压和糖尿病。鉴于白内障在全球的高发病率,与白内障相关的视力损伤造成了巨大的负担,这凸显了对药物策略的需求,以补充手术干预措施。了解白内障发生过程中氧化应激所涉及的分子通路可为设计新型治疗方法提供宝贵的见解。本综述探讨了氧化应激在白内障形成过程中的作用,重点关注线粒体功能障碍、内质网应激、间隙连接缺失以及 LECs 中的各种细胞死亡途径等关键机制。此外,我们还讨论了新出现的治疗策略和潜在的靶向选择,包括基于抗氧化剂的治疗方法。
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Oxidative Stress in Cataract Formation: Is There a Treatment Approach on the Horizon?

Cataracts, a leading cause of blindness worldwide, are closely linked to oxidative stress-induced damage to lens epithelial cells (LECs). Key factors contributing to cataract formation include aging, arterial hypertension, and diabetes mellitus. Given the high global prevalence of cataracts, the burden of cataract-related visual impairment is substantial, highlighting the need for pharmacological strategies to supplement surgical interventions. Understanding the molecular pathways involved in oxidative stress during cataract development may offer valuable insights for designing novel therapeutic approaches. This review explores the role of oxidative stress in cataract formation, focusing on critical mechanisms, such as mitochondrial dysfunction, endoplasmic reticulum stress, loss of gap junctions, and various cell death pathways in LECs. Additionally, we discuss emerging therapeutic strategies and potential targeting options, including antioxidant-based treatments.

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来源期刊
Antioxidants
Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍: Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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