顺序胚胎移植对反复植入失败患者妊娠结局的影响:随机对照试验的系统回顾和荟萃分析。

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Archives of Gynecology and Obstetrics Pub Date : 2024-10-23 DOI:10.1007/s00404-024-07764-z
Saeed Baradwan, Majed Saeed Alshahrani, Hussein Sabban, Nabigah Alzawawi, Hanin Hassan Abduljabbar, Afnan Baradwan, Mohamed Anwar Haroun, Ahmed Alanwar, Mohamed Ali Mohamed, Yousef Mohamed El-Mazzally, Ahmed Mohamed Abdelhakim, Yasser Khamis
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引用次数: 0

摘要

研究目的我们的研究旨在评估顺序胚胎移植对复发性植入失败(RIF)患者妊娠结局的影响:我们在各种数据库中全面检索了从开始到 2024 年 1 月期间符合条件的临床试验。如果随机对照试验(RCT)对反复着床失败的不孕妇女进行了包括卵裂期胚胎和囊胚期胚胎的顺序胚胎移植与其他移植方案的比较,则纳入这些试验。使用 Revman 软件进行了元分析。我们主要关注的是持续妊娠率。我们的次要指标包括化学妊娠率、临床妊娠率、流产率和多胎妊娠率:有 7 项研究符合纳入标准,涉及 909 名患者。与对照组相比,序贯胚胎移植显著提高了持续妊娠率(OR = 2.28,95% CI [1.46,3.56],P = 0.003)。此外,顺序胚胎移植组的化学妊娠率和临床妊娠率也有明显提高。在多胎妊娠率和流产率方面,组间差异无统计学意义(P > 0.05):结论:顺序胚胎移植有望改善 RIF 患者的妊娠结局。结论:顺序胚胎移植有望提高 RIF 患者的妊娠结局,但还需要更多试验来验证我们的研究结果。
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The effect of sequential embryo transfer on pregnancy outcomes in patients with recurrent implantation failure: a systematic review and meta-analysis of randomized controlled trials.

Objective: The aim of our study was to assess the impact of sequential embryo transfer on pregnancy outcomes among patients with recurrent implantation failure (RIF).

Methods: We conducted a comprehensive search across various databases for eligible clinical trials from inception to January 2024. Randomized controlled trials (RCTs) were included if they compared sequential embryo transfer, comprising both cleavage-stage and blastocyst-stage embryos, with other transfer protocols in infertile women with repeated implantation failure. Meta-analysis was performed using Revman software. Our primary focus was on the ongoing pregnancy rate. Our secondary measures included rates of chemical pregnancies, clinical pregnancies, miscarriages, and multiple pregnancies.

Results: Seven RCTs, encompassing 909 patients, met the inclusion criteria. Sequential embryo transfer demonstrated a significant increase in the ongoing pregnancy rate compared to the control group (OR = 2.28, 95% CI [1.46, 3.56], p = 0.003). Moreover, the sequential embryo transfer group exhibited notable improvements in chemical and clinical pregnancy rates. There were no statistically significant differences between the groups regarding multiple pregnancy and miscarriage rates (p > 0.05).

Conclusions: Sequential embryo transfer shows promise in enhancing pregnancy outcomes among RIF patients. However, additional trials are warranted to validate our findings.

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来源期刊
CiteScore
4.70
自引率
15.40%
发文量
493
审稿时长
1 months
期刊介绍: Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.
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