终生慢性压力暴露、压力荷尔蒙和生物衰老:美国中年(MIDUS)研究结果。

IF 8.8 2区 医学 Q1 IMMUNOLOGY Brain, Behavior, and Immunity Pub Date : 2024-10-21 DOI:10.1016/j.bbi.2024.10.022
Jenna L Hansen, Judith E Carroll, Teresa E Seeman, Steve W Cole, Kelly E Rentscher
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引用次数: 0

摘要

社会心理压力和逆境与加速衰老和增加罹患老年相关疾病的风险有关。动物和体外研究表明,暴露于应激激素(儿茶酚胺、糖皮质激素)会影响 DNA 损伤和细胞衰老等生物衰老过程,这表明它们在应激和衰老之间的联系中起着关键作用;然而,这些联系在人类中还没有得到很好的研究。我们研究了中年成人长期压力暴露、压力荷尔蒙和生物衰老标志物之间的横断面关联,以及压力荷尔蒙是否介导了压力和衰老之间的关联。研究对象是具有全国代表性的美国中年进修队列中的 531 名 26-78 岁成年人(年龄 = 53.9,女性占 50.1%)。他们报告了童年和成年时所遭受的慢性压力(生活压力事件量表),并提供了用于评估去甲肾上腺素、肾上腺素和皮质醇的 12 小时尿样。外周血单核细胞的 RNA 测序得出了衰老生物标志物:DNA 损伤反应(DDR;30 个基因合成)、细胞衰老信号 p16INK4a (CDKN2A) 和促炎症衰老相关分泌表型(SASP;57 个基因合成)。对年龄、性别、种族/民族、体重指数、吸烟状况、饮酒和药物进行调整后的回归模型显示,童年时期接触较多的去甲肾上腺素较高(β = 0.09,p = 0.04),这与成人接触无关。较高的去甲肾上腺素与 DDR 表达的升高有关(β = 0.17,p = 0.04)。
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Lifetime chronic stress Exposures, stress Hormones, and biological Aging: Results from the midlife in the United States (MIDUS) study.

Psychosocial stress and adversity have been linked to accelerated aging and increased risk for age-related diseases. Animal and in vitro studies have shown that exposure to stress hormones (catecholamines, glucocorticoids) can impact biological aging processes such as DNA damage and cellular senescence, suggesting they play a key role in links between stress and aging; however, these associations have not been well investigated in humans. We examined cross-sectional associations between chronic stress exposures, stress hormones, and biological aging markers in midlife adults and whether stress hormones mediated associations between stress and aging. Participants were 531 adults aged 26-78 years (Mage = 53.9, 50.1 % female) in the nationally representative Midlife in the United States Refresher cohort. They reported chronic stress exposures in childhood and adulthood (Stressful Life Event Inventory) and provided 12-hour urine samples used to assess norepinephrine, epinephrine, and cortisol. RNA sequencing of peripheral blood mononuclear cells derived aging biomarkers: the DNA damage response (DDR; 30-gene composite), cellular senescence signal p16INK4a (CDKN2A), and the pro-inflammatory senescence-associated secretory phenotype (SASP; 57-gene composite). Regression models adjusting for age, sex, race/ethnicity, BMI, smoking status, alcohol use, and medications revealed that more childhood exposures were associated with higher norepinephrine (β = 0.09, p = 0.04), independent from adult exposures. Higher norepinephrine was associated with elevated DDR expression (β = 0.17, p < 0.001). Higher norepinephrine (β = 0.14, p = 0.003) and epinephrine (β = 0.10, p = 0.02) were both associated with elevated SASP expression. Statistical mediation analyses implicated elevated norepinephrine as a plausible mediator of associations between childhood exposures and both DDR (unstandardized b = 0.005, 95 % CI [0.0002, 0.011]) and SASP (b = 0.002, 95 % CI [0.0001, 0.05]). Findings provide preliminary evidence in humans that stress hormones may impact key biological aging processes and may be a mechanism linking chronic stress exposures in childhood to accelerated aging later in life.

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来源期刊
CiteScore
29.60
自引率
2.00%
发文量
290
审稿时长
28 days
期刊介绍: Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.
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