人多力量大--在大型卫生组织队列中发现高血清铁蛋白水平与新诊断出的恶性肿瘤之间存在显著关联。

IF 3.7 3区 医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-10-24 DOI:10.1158/1055-9965.EPI-24-0757
Alon Simchovitz Gesher, Keren Grinin, Dor Atias, Tal Patalon, Sivan Gazit, Moshe Hoshen, Amir Dagan
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引用次数: 0

摘要

背景:铁蛋白是一种铁储存蛋白和急性时相反应物,与人类健康和疾病(包括癌症)的各个方面都有关系。以前的研究已发现几种癌症类型的血清铁蛋白(SF)水平升高,但仍缺乏对不同恶性肿瘤的全面检查。本研究旨在利用以色列最大的医疗机构之一马卡比医疗服务公司(Maccabi Health Services,MHS)的匿名数据填补这一空白,探讨 SF 水平升高与不同恶性肿瘤诊断之间的关联:方法:分析了马卡比医疗服务的大量数据集,这些数据集包括 270 万名会员,其中 130 万人接受了 SF 水平检测。计算了几率比(OR)和95%置信区间(CI),以评估高SF水平与癌症诊断之间的关联。还进行了分组分析,以研究不同恶性肿瘤之间的差异:分析结果显示,在MHS成员中,SF水平升高与癌症诊断之间存在明显的关联,OR值为1.9(95% CI为1.71-2.15)。分组分析揭示了不同恶性肿瘤类型之间的关联差异,血液、肝胆和呼吸系统恶性肿瘤与 SF 水平高的关联度更高:这项研究进一步证实了 SF 水平升高与恶性肿瘤之间的联系,利用了来自 MHS 的大量数据集,强调了 SF 水平升高作为癌症潜在指标的潜在作用,在不同恶性肿瘤类型中的作用各不相同:对于看似健康的人来说,将 SF 水平升高确定为潜在恶性肿瘤的潜在指标。
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Strength in Numbers - Identifying a Significant Association Between High Serum Ferritin Levels and Newly diagnosed Malignancy in a Large Health Organization Cohort.

Background: Ferritin, an iron storage protein and acute phase reactant, has been implicated in various aspects of human health and disease, including cancer. Previous studies have identified elevated serum ferritin (SF) levels in several cancer types, but a comprehensive examination across different malignancies remains lacking. This study aims to fill this gap by utilizing anonymized data from Maccabi Health Services (MHS), one of Israel's largest health organizations, to explore the association between elevated SF levels and the diagnosis of different malignancies.

Methods: An extensive dataset from MHS, comprising 2.7 million members, including 1.3 million individuals who underwent SF level testing, was analyzed. Odds Ratios (OR) and 95% confidence intervals (CI) were calculated to assess the association between high SF levels and cancer diagnosis. Subgroup analysis was conducted to investigate variations across different malignancies.

Results: The analysis revealed a significant association between elevated SF levels and cancer diagnosis among MHS members, with an OR of 1.9 (95% CI 1.71-2.15). Sub- group analysis unveiled differences in the association across malignancy types, with hematological, hepatobiliary and respiratory malignancies more strongly associated with high SF levels.

Conclusions: This study provides further support for the link between elevated SF levels and malignancy, leveraging a vast dataset from MHS, underscoring potential utilities of elevated SF levels as a potential indicator for cancer with a variable role among different malignancy types.

Impact: The identification of elevated SF levels as a potential indicator for underlying malignancy for seemingly-healthy individuals.

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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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