微型评论：作为治疗工具的 Tregs--明显和不明显的挑战与解决方案

IF 5.1 2区生物学 Q2 CELL BIOLOGY Cells Pub Date : 2024-10-11 DOI:10.3390/cells13201680

Elena I Morgun, Irina A Govorova, Maria B Chernysheva, Maria A Machinskaya, Ekaterina A Vorotelyak

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引用次数: 0

摘要

集落细胞有可能被用作治疗糖尿病、阿尔茨海默病、哮喘和类风湿性关节炎等各种慢性疾病的新型治疗剂。开发基于 Tregs 的治疗产品所面临的挑战之一是多克隆细胞的非选择性。解决这一问题的潜在办法是产生抗原特异性 CAR-Tregs。开发基于Tregs的治疗产品所面临的其他挑战包括：这些细胞在炎症微环境中的表型不稳定、工程Treg样细胞与天然Tregs之间的差异，以及Treg标记基因的功能障碍异构体的表达。本综述概述了应对这些挑战的拟议策略。

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Mini-Review: Tregs as a Tool for Therapy-Obvious and Non-Obvious Challenges and Solutions.

Tregs have the potential to be utilized as a novel therapeutic agent for the treatment of various chronic diseases, including diabetes, Alzheimer's disease, asthma, and rheumatoid arthritis. One of the challenges associated with developing a therapeutic product based on Tregs is the non-selectivity of polyclonal cells. A potential solution to this issue is a generation of antigen-specific CAR-Tregs. Other challenges associated with developing a therapeutic product based on Tregs include the phenotypic instability of these cells in an inflammatory microenvironment, discrepancies between engineered Treg-like cells and natural Tregs, and the expression of dysfunctional isoforms of Treg marker genes. This review presents a summary of proposed strategies for addressing these challenges.

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来源期刊

Cells Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

9.90

自引率

5.00%

发文量

3472

审稿时长

16 days

期刊介绍： Cells (ISSN 2073-4409) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to cell biology, molecular biology and biophysics. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.