过氧化物酶体增殖物激活受体在免疫介导的肠道疾病中的多种作用。

IF 5.1 2区生物学 Q2 CELL BIOLOGY Cells Pub Date : 2024-10-12 DOI:10.3390/cells13201688

Edit Posta, Istvan Fekete, Istvan Varkonyi, Eva Zold, Zsolt Barta

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引用次数: 0

摘要

过氧化物酶体增殖激活受体（PPARs）是一种核受体，能感知亲脂分子，并作为转录因子调节靶基因。PPAR 与先天性免疫、葡萄糖和脂质代谢、细胞增殖、伤口愈合和纤维化过程的调节有关。一些合成的 PPAR 配体是治疗免疫介导的肠道疾病中炎症和纤维化过程的有前途的分子。其中一些正在进行或已经进行过临床试验。根据动物模型和临床试验，膳食 PPAR 配体和微生物群组成的变化可调节 PPAR 的活化，从而减轻这些免疫介导疾病的炎症反应。本综述旨在总结 PPARs 在免疫介导的肠道疾病中的作用及其潜在的治疗用途。

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The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases.

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that sense lipophilic molecules and act as transcription factors to regulate target genes. PPARs have been implicated in the regulation of innate immunity, glucose and lipid metabolism, cell proliferation, wound healing, and fibrotic processes. Some synthetic PPAR ligands are promising molecules for the treatment of inflammatory and fibrotic processes in immune-mediated intestinal diseases. Some of these are currently undergoing or have previously undergone clinical trials. Dietary PPAR ligands and changes in microbiota composition could modulate PPARs' activation to reduce inflammatory responses in these immune-mediated diseases, based on animal models and clinical trials. This narrative review aims to summarize the role of PPARs in immune-mediated bowel diseases and their potential therapeutic use.

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来源期刊

Cells Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

9.90

自引率

5.00%

发文量

3472

审稿时长

16 days

期刊介绍： Cells (ISSN 2073-4409) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to cell biology, molecular biology and biophysics. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.