幽门螺杆菌阴性胃黏膜相关淋巴组织淋巴瘤的比例和特征:系统回顾与荟萃分析。

IF 3 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Clinical and Translational Gastroenterology Pub Date : 2024-10-25 DOI:10.14309/ctg.0000000000000781
Xiu-He Lv, Qing Lu, Jia-Huan Liu, Bi-Han Xia, Zi-Jing Wang, Zhu Wang, Jin-Lin Yang
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引用次数: 0

摘要

背景:幽门螺杆菌(H. pylori)感染在胃黏膜相关淋巴组织(MALT)淋巴瘤患者中很常见,但仍有检测结果为阴性的患者。这些患者的比例和特征仍不清楚:我们对 PubMed、Embase 和 Cochrane Library 数据库中的相关文章进行了系统检索。我们使用随机效应模型进行了荟萃分析,以评估幽门螺杆菌检测呈阴性的胃 MALT 淋巴瘤患者的总体比例。此外,我们还比较了有幽门螺杆菌感染和无幽门螺杆菌感染的胃MALT淋巴瘤患者的特征,以研究幽门螺杆菌阴性病例的临床特点:结果:共纳入了 50 项研究,涉及 6033 名患者。幽门螺杆菌检测阴性的胃MALT淋巴瘤患者总比例为20.5%(95%置信区间:17.0%-24.6%)。这一比例呈逐年上升趋势,尤其是在非亚洲国家和2013年以后发表的研究中,以及在样本量超过100人的病例中、男性患者中、有近端或多发病灶、非浅表型形态、粘膜下侵犯和晚期临床分期的患者中。与幽门螺杆菌阳性患者相比,检测结果为阴性的患者更有可能是男性、有近端病变、表现出粘膜下侵犯以及临床分期较晚:本研究提供了幽门螺杆菌阴性胃MALT淋巴瘤病例比例和特征的全面信息,强调了未来临床上需要关注这一患者群体的治疗和监测。
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Proportion and characteristics of Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma: A systematic review and meta-analysis.

Background: While Helicobacter pylori (H. pylori) infection is common in patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma, there are still individuals who test negative for it. The proportion and characteristics of these patients remain unclear.

Methods: We conducted a systematic search of the PubMed, Embase, and Cochrane Library databases for relevant articles. Using a random effects model, we performed a meta-analysis to assess the pooled proportion of gastric MALT lymphoma patients with negative H. pylori tests. Additionally, we compared characteristics between gastric MALT lymphoma patients with and without H. pylori infection to examine clinical features in H. pylori-negative cases.

Results: A total of 50 studies involving 6033 patients were included. The overall proportion of gastric MALT lymphoma patients with negative H. pylori tests was 20.5% (95% confidence interval: 17.0%-24.6%). This rate exhibited an increasing trend over the years, particularly in non-Asian countries and in studies published after 2013, as well as in cases with sample sizes exceeding 100 participants, in male individuals, and among those with proximal or multiple lesions, non-superficial type morphology, submucosal invasion, and advanced clinical staging. Compared to H. pylori-positive patients, those who tested negative were more likely to be male, have proximal lesions, exhibit submucosal invasion, and present with an advanced clinical stage.

Conclusions: This study provides comprehensive information on the proportion and characteristics of H. pylori-negative gastric MALT lymphoma cases, highlighting the need for future clinical attention to treatment and surveillance in this patient population.

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来源期刊
Clinical and Translational Gastroenterology
Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
7.00
自引率
0.00%
发文量
114
审稿时长
16 weeks
期刊介绍: Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.
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