温度升高会增加大型蚤对卡马西平、曲马多和西酞普兰环境混合物的敏感性。

IF 3.9 3区 环境科学与生态学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Comparative Biochemistry and Physiology C-toxicology & Pharmacology Pub Date : 2024-10-20 DOI:10.1016/j.cbpc.2024.110052
András Ács , János Schmidt , Zoltán Németh , István Fodor , Anna Farkas
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引用次数: 0

摘要

对地表水中的热应力和不断增加的药物(PhACs)负荷进行联合风险评估是水生生态毒理学的一个相关课题。本研究调查了水温升高与改变环境相关的卡马西平(CBZ)、西酞普兰(CIT)和曲马多(TRA)混合物(ECs)的急性毒性以及大型蚤的延迟结果之间的相关性。在 21 ℃ 和 26 ℃ 培养条件下,研究了早熟水蚤在急性接触 PhACs 混合物 24 小时(脉冲)后的解毒和抗氧化途径反应,以及 14 天恢复期生殖输出的延迟反应。在两种温度条件下都观察到谷胱甘肽 S-转移酶(GST)活性的双相调节和超氧化物歧化酶(SOD)活性的显著抑制,有效阈值从 21 °C孵育时的 10 倍 ECs 显著转移到 26 °C孵育时的 ECs。在温度升高的情况下,从10倍ECs剂量开始,过氧化氢酶(CAT)活性显著增强,氧化应激发展。在 26 °C下的脉冲暴露也会导致水蚤的繁殖率显著下降,超过 PhACs 的 10 倍 ECs 剂量。综合生物标记反应评分法(IBRv2)显示,在 26 °C、100 倍浓度的 PhACs 下,水蚤的变化增加了 1.8 倍。
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Elevated temperature increases the susceptibility of D. magna to environmental mixtures of carbamazepine, tramadol and citalopram
The joint risks assessment of thermal stress and rising loads of pharmaceuticals (PhACs) in surface waters is a relevant topic in aquatic ecotoxicology. This study investigated the relevance of increased water temperature to alter the acute toxicity of environmentally relevant carbamazepine (CBZ), citalopram (CIT) and tramadol (TRA) concentrations as mixtures (ECs) and delayed outcomes in Daphnia magna. Responses of detoxification and antioxidant pathways in premature daphnids post an acute 24 h (pulsed) exposure to the PhACs mixtures and delayed responses as the reproductive output over 14 days recovery were investigated under 21- and 26 °C incubation. Biphasic modulation in glutathione S-transferase (GST) activity and significant inhibition of superoxide dismutase (SOD) activity were observed in both thermal regimes with significant shift in effective thresholds from 10-fold ECs at 21 °C to ECs at 26 °C incubation. Significant induction in catalase (CAT) activity and oxidative stress development were recorded at elevated temperatures from the 10-fold ECs dose onward. Pulsed exposures at 26 °C also led to significant decrease in the reproduction of daphnids above the 10-fold ECs of PhACs. The Integrated Biomarker Response scoring (IBRv2) approach outlined a 1.8-fold increase in alterations of daphnids exposed to 100-fold ECs of PhACs at 26 °C.
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来源期刊
CiteScore
7.50
自引率
5.10%
发文量
206
审稿时长
30 days
期刊介绍: Part C: Toxicology and Pharmacology. This journal is concerned with chemical and drug action at different levels of organization, biotransformation of xenobiotics, mechanisms of toxicity, including reactive oxygen species and carcinogenesis, endocrine disruptors, natural products chemistry, and signal transduction with a molecular approach to these fields.
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