与濒危针叶树 Pinus wangii 相关的 Nigrospora sphaerica MZW-A 内生菌中的茄碱类似物。

IF 2.5 3区 医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-10-23 DOI:10.1016/j.fitote.2024.106275
Mengran Wang, Haowei Chen, Lihong Yan, Jingtao Chen, Lu Gan, Zhichun Shen, Juan Xiong, Jinfeng Hu, Jiyang Li
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引用次数: 0

摘要

本研究从 Nigrospora sphaerica MZW-A 的固体发酵产物中获得了 8 种以前未曾描述过的茄并吡喃酮类似物--sphasolanapyrones A-H (1-8),以及 4 种结构相关的已知化合物(9-12),Nigrospora sphaerica MZW-A 是一种从濒危针叶树 Pinus wangii 的新鲜枝条中分离出来的内生真菌。这项研究是首次对与这种珍贵植物相关的内生真菌的次级代谢产物进行研究。通过大量光谱分析和电子圆二色性(ECD)计算,阐明了 1-8 号化合物的结构和绝对构型。1 和 2 是 3,4-vic 二醇茄并吡喃酮类似物的第一个例子,而 7 和 8 则是罕见的 17-去甲茄并吡喃酮。在这些分离物中,3、4、5 和 11 对金黄色葡萄球菌有微弱的抑制作用。此外,化合物 5 对几种肿瘤细胞株有微弱的细胞毒性作用。
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Solanapyrone analogues from endophytic Nigrospora sphaerica MZW-A associated with the endangered conifer Pinus wangii.

Eight previously undescribed solanapyrone analogues, sphasolanapyrones A-H (1-8), together with four structurally related known compounds (9-12) were obtained from the solid fermentation of Nigrospora sphaerica MZW-A, an endophytic fungus isolated from the fresh branches of the endangered conifer Pinus wangii. This study represents the first investigation on the secondary metabolites of endophytic fungus associated with this precious plant. The structures and absolute configurations of compounds 1-8 were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. 1 and 2 are first examples of 3,4-vic diol solanapyrone analogues, whereas 7 and 8 are rare 17-nor-solanapyrones. Among these isolates, 3, 4, 5, and 11 showed weak inhibitory against Staphylococcus aureus. In addition, compound 5 displayed weak cytotoxic effects against several tumor cell lines.

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来源期刊
Fitoterapia
Fitoterapia 医学-药学
CiteScore
5.80
自引率
2.90%
发文量
198
审稿时长
1.5 months
期刊介绍: Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
期刊最新文献
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