CLINICAL, IMMUNOLOGICAL AND THESIOGRAPHIC CHARACTERISTICS RHEUMATOID ARTHRITIS AND CHRONIC RHEUMATIC HEART DISEASE.

Rheumatism and rheumatic diseases have not yet lost their problematic and relevance for medicine and society. In terms of their prevalence, they occupy the third place after diseases of the cardiovascular system and digestive organs. In this regard, it is relevant to study the clinical and pathogenetic aspects of rheumatism and rheumatoid arthritis associated with persistent nasopharyngeal infection, as well as to search for new effective approaches to the treatment of these diseases, making the most significant contribution to the formation of irreversible changes in the heart and musculoskeletal system.

Materials and methods: Archival medical records of inpatient and outpatient patients of city and region-al clinical hospitals, city polyclinics of Shymkent were studied, and the current situation in Shymkent was studied based on morbidity indicators. The sample was solid.

Results: We evaluated some clinical, laboratory and radiological parameters in patients with seropositive and seronegative RA course. The slow-progressive type of onset of the disease was more often observed in patients with seronegative RA- 71.4% versus 52.8%. The two subgroups were dominated by patients with II degree of activity 57.1%- 61.1%. II and III radiological stages were observed in the majority of patients with seronegative and seropositive variants of the course: 92.9% and 83.3%, respectively.

Conclusion: The physico-chemical properties of the blood plasma of patients with chronic rheumatic heart disease and rheumatoid arthritis deteriorated significantly: systemic and subsystem structural disorders in thesiographic patterns were noted, having distinctive features for rheumatic heart disease and rheumatoid arthritis.